Albert R, Merz A, Schubert J, Ebert D
Psychiatrische Universitätsklinik mit Poliklinik, Erlangen.
Nervenarzt. 1998 Jan;69(1):66-9. doi: 10.1007/s001150050240.
Approximately 60% of patients with major depression disorder show a beneficial response to total sleep deprivation (TSD), but the positive effect of TSD is short, and naps or the following night's sleep destroy it. Various methods have been tried to stabilize the positive sleep-deprivation effect. A consecutive 1-week advance in the sleep phase stabilized mood in more than 50% of the sleep-deprivation responders. We examined 40 male patients with major depression who in addition to medical treatment took part in a phase advance study to prove possible synergistic effects. About 60% of the patients showed positive mood stabilization after 1-week of treatment when the patients were sleep-deprivation responders. These results support data from other groups.
约60%的重度抑郁症患者对完全睡眠剥夺（TSD）表现出有益反应，但TSD的积极效果持续时间较短，小睡或随后一晚的睡眠会破坏这种效果。人们尝试了各种方法来稳定睡眠剥夺的积极效果。睡眠阶段连续提前1周可使超过50%的睡眠剥夺反应者情绪稳定。我们研究了40名重度抑郁症男性患者，这些患者除接受药物治疗外，还参与了一项相位提前研究，以证明可能的协同效应。约60%的患者在接受1周治疗后情绪得到积极稳定，这些患者为睡眠剥夺反应者。这些结果支持了其他研究小组的数据。
