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[内镜逆行胰胆管造影术后并发铜绿假单胞菌血症]

[Pseudomonas aeruginosa bacteremia as a complication after endoscopic retrograde cholangiopancreatography].

作者信息

Rodríguez Guardado A, Maradona J A, Cartón J A, Hooker N, Alonso J L, Asensi V, Arribas J M

机构信息

Unidad de Enfermedades Infecciosas (Servicio de Medicina Interna), Hospital Central de Asturias.

出版信息

Enferm Infecc Microbiol Clin. 1997 Dec;15(10):540-3.

PMID:9522518
Abstract

BACKGROUND

The present was performed to describe the characteristics of bacteremias by Pseudomonas aeruginosa following cholangiopancreatography and the methods of prevention and treatment of the same.

METHODS

Twelve different episodes of bacteremia by Pseudomonas aeruginosa were retrospectively studied in patients submitted to endoscopic cholangiopancreatography (ERCP) from 1993-1997.

RESULTS

Three point six percent of the patients undergoing ERCP presented episodes of bacteremias by the microorganism in the 48 hours following the procedure. Except for one case, the patients presented obstructive disease in the form of calculi or neoplasms at the level of the biliary tree. In three cases, sphincterotomy had been carried out which was followed by clinical manifestations of hemorrhage in one case. Three patients (25%) died as a consequence of bacteremia and a hepatic abscess was developed in one case. The bacteremia appeared in successive outbreaks from 1993-1997.

CONCLUSIONS

Bacteremia by Pseudomonas aeruginosa following ERCP is more frequent in patients with obstructive disease of the biliary tract and has an important additional morbimortality. It is associated with incorrect endoscopic disinfection. The use of drugs with an antipseudomonal spectrum should be considered as preendoscopic prophylaxis.

摘要

背景

本研究旨在描述胆管胰管造影术后铜绿假单胞菌所致菌血症的特征及其防治方法。

方法

回顾性研究了1993年至1997年接受内镜胆管胰管造影术(ERCP)的患者中12例不同的铜绿假单胞菌菌血症发作情况。

结果

接受ERCP的患者中有3.6%在术后48小时内出现该微生物所致菌血症发作。除1例患者外,其余患者在胆管树水平存在结石或肿瘤形式的梗阻性疾病。3例患者进行了括约肌切开术,其中1例术后出现出血临床表现。3例患者(25%)因菌血症死亡,1例患者并发肝脓肿。菌血症在1993年至1997年呈连续爆发出现。

结论

ERCP术后铜绿假单胞菌所致菌血症在胆道梗阻性疾病患者中更为常见,且具有重要的额外病死风险。它与内镜消毒不当有关。应考虑使用具有抗假单胞菌谱的药物作为内镜术前预防用药。

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