围绕内质网伴侣蛋白GRP94/gp96的生化、细胞生物学及免疫学问题。
Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96.
作者信息
Nicchitta C V
机构信息
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Curr Opin Immunol. 1998 Feb;10(1):103-9. doi: 10.1016/s0952-7915(98)80039-3.
PMID:9523119
Abstract
The past year has born witness to compelling demonstrations of the utility of peptide complexes with glucose regulated protein 94 (GRP94, also known as gp96) in cancer immunotherapy. Insights into the structural basis of peptide binding to GRP94 have been obtained and the role of the transporter for antigen presentation in defining the GRP94-bound peptide composition has been determined.
摘要
过去一年见证了肽与葡萄糖调节蛋白94（GRP94，也称为gp96）复合物在癌症免疫治疗中的效用的令人信服的证明。已经获得了对肽与GRP94结合的结构基础的深入了解，并确定了抗原呈递转运体在确定GRP94结合肽组成中的作用。
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