Slayback J B, Bowen W W, Hinshaw D B
Am J Surg. 1976 Aug;132(2):183-8. doi: 10.1016/0002-9610(76)90045-3.
Preliminary experimental data have been presented indicating that intimal injury of some degree is a virtually constant finding at the site of application of any arterial occluding clamp. These injuries vary from intimal distortion to complete fracture into the media of the vessel. The degree of injury appears directly proportional to the amount of pressure exerted through a given clamp. Atherosclerotic arteries are particularly subject to severe degrees of intimal injury. Preliminary observations suggest that heparin is not helpful in preventing platelet aggregation and initial thrombus formation at intimal injury sites. The problem of anticoagulation at such injury sites is being studied further.
初步实验数据表明，在任何动脉阻断钳应用部位，某种程度的内膜损伤几乎是一个恒定的发现。这些损伤范围从内膜变形到完全断裂进入血管中膜。损伤程度似乎与通过特定钳子施加的压力大小直接成正比。动脉粥样硬化的动脉尤其容易受到严重程度的内膜损伤。初步观察表明，肝素无助于预防内膜损伤部位的血小板聚集和初始血栓形成。此类损伤部位的抗凝问题正在进一步研究中。
