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[脐带血和新生儿血中淋巴细胞表型的细胞计数分析]

[Cytometric analysis of lymphocyte phenotype in cord and newborn blood].

作者信息

Banasik M, Zeman K, Malinowski A, Pociechowski L, Helwich E, Tchórzewski H

机构信息

Pracowni Cytometrii Przepływowej Zakładu Immunologii Klinicznej CZMP.

出版信息

Pol Merkur Lekarski. 1997 Nov;3(17):236-40.

PMID:9523481
Abstract

At birth and in early childhood, phenotypic and functional investigation of the immune system is often necessary to identify primary immunological disorders and may provide additional diagnostic and prognostic information in certain intrauterine infections. We compared, using of flow cytometric immunophenotyping, a broad panel of lymphocyte subsets in paired samples obtained from healthy infants at birth (cord blood) and at 3 days of age. Results were compared to those of normal children (7 to 17 years) evaluated using the same methods. Significant age-related differences were demonstrated in lymphocyte subpopulations. Our data can be used as age-matched reference values for blood lymphocyte immunophenotyping.

摘要

在出生时和儿童早期,对免疫系统进行表型和功能研究通常对于识别原发性免疫疾病是必要的,并且在某些宫内感染中可能提供额外的诊断和预后信息。我们使用流式细胞术免疫表型分析,比较了从健康婴儿出生时(脐带血)和3日龄时获取的配对样本中的一组广泛的淋巴细胞亚群。将结果与使用相同方法评估的正常儿童(7至17岁)的结果进行比较。在淋巴细胞亚群中显示出显著的年龄相关差异。我们的数据可作为血液淋巴细胞免疫表型分析的年龄匹配参考值。

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