The relationship between the putative optic pathway potential and the electroretinogram.

The putative optic pathway flash visual evoked potential (FVEP) and the electroretinogram (ERG) were recorded consecutively in the lightly anesthetised rat. The purpose was to test the hypothesis that the optic pathway FVEP is only an artifact created by distorted volume-conducted retinal activity. A comparison of the timing of the ERG with that of the optic pathway FVEP confirmed this suspicion. It is shown that there is a close temporal correspondence between individual subcomponents of the optic pathway potential and those of the ERG (i.e., the a-wave, b-wave, and the oscillatory potentials). In addition, it was found that when ERG currents are recorded far field from the vicinity of the optic nerve or tract, they acquire a triphasic positive-negative-positive waveform, thereby heightening the illusion that the optic pathway FVEP is a genuine compound action potential. It is concluded that experimental findings derived from the recording of the optic pathway FVEP must be treated with caution.