Shaw N A
Department of Physiology, School of Medicine, University of Auckland, New Zealand.
Physiol Behav. 1998 Feb 15;63(4):615-20. doi: 10.1016/s0031-9384(97)00509-x.
The putative optic pathway flash visual evoked potential (FVEP) and the electroretinogram (ERG) were recorded consecutively in the lightly anesthetised rat. The purpose was to test the hypothesis that the optic pathway FVEP is only an artifact created by distorted volume-conducted retinal activity. A comparison of the timing of the ERG with that of the optic pathway FVEP confirmed this suspicion. It is shown that there is a close temporal correspondence between individual subcomponents of the optic pathway potential and those of the ERG (i.e., the a-wave, b-wave, and the oscillatory potentials). In addition, it was found that when ERG currents are recorded far field from the vicinity of the optic nerve or tract, they acquire a triphasic positive-negative-positive waveform, thereby heightening the illusion that the optic pathway FVEP is a genuine compound action potential. It is concluded that experimental findings derived from the recording of the optic pathway FVEP must be treated with caution.
在轻度麻醉的大鼠中连续记录假定的视路闪光视觉诱发电位（FVEP）和视网膜电图（ERG）。目的是检验视路FVEP只是由扭曲的容积传导视网膜活动产生的伪像这一假设。将ERG的时间与视路FVEP的时间进行比较证实了这一怀疑。结果表明，视路电位的各个子成分与ERG的子成分（即a波、b波和振荡电位）之间存在密切的时间对应关系。此外，还发现当从视神经或视束附近远处记录ERG电流时，它们会获得一个三相正负正波形，从而增强了视路FVEP是真正复合动作电位的错觉。得出的结论是，对视路FVEP记录得出的实验结果必须谨慎对待。
