奎尼丁对离体犬心房去甲肾上腺素反应无阻断作用。
Absence of blocking effect of quinidine on responses to norepinephrine in the isolated dog atrium.
作者信息
Chiba S
出版信息
Jpn Heart J. 1976 Jul;17(4):506-11. doi: 10.1536/ihj.17.506.
PMID:9524
Abstract
The isolated right dog atrium was perfused through the sinus node artery with blood led from a heparinized support dog under constant perfusion pressure of 100 mmHg. The positive chronotropic and inotropic responses to norepinephrine were not significantly suppressed by treatment with large amounts of quinidine or procainamide, but completely blocked by propranolol. From these results, it was demonstrated that quinidine and procainamide have no adrenergic beta-blocking activity on chronotropism and on inotropism in the heart.
摘要
将分离出的犬右心房通过窦房结动脉，用来自一只肝素化的供血犬的血液进行灌注，灌注压力恒定为100 mmHg。用大量奎尼丁或普鲁卡因胺处理后，对去甲肾上腺素的正性变时和变力反应未受到显著抑制，但被普萘洛尔完全阻断。从这些结果可以证明，奎尼丁和普鲁卡因胺对心脏的变时性和变力性没有肾上腺素能β受体阻断活性。
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