Korsak Z, Rydzyński K, Jajte J
Department of Toxicity and Carcinogenesis, Nofer Institute of Occupational Medicine, Lódź, Poland.
Int J Occup Med Environ Health. 1997;10(3):303-11.
Sensory respiratory irritation effects of trimethylbenzene isomers (TMBs) (hemimellitene, mesitylene and pseudocumene) in male Balb/C mice were investigated in conditions of acute exposure and in male Wistar rats in conditions of repeated 90-day inhalation exposure to pseudocumene. The pseudocumene, mesitylene and hemimellitene concentrations depressing the respiratory rate to 50% (RD50) were 578, 519, 541 ppm, respectively. Inhalation exposure to pseudocumene for 90 days increased the total number of cell macrophages, polymorphonuclear leukocytes and lymphocytes number at all three test concentrations compared with the controls. Total protein lactate dehydrogenase (LDH) and acid phosphatase activity in bronchoalveolar lavage (BAL) were significantly increased in all exposed groups. Based on the effects observed in the respiratory tract, the threshold limit value of at least 10 ppm should be considered for the occupational exposure to trimethylbenzene isomers.
研究了三甲苯异构体（TMBs，即偏三甲苯、均三甲苯和连三甲苯）对雄性Balb/C小鼠的急性暴露条件下以及对雄性Wistar大鼠重复90天吸入连三甲苯条件下的呼吸道感觉刺激作用。使呼吸频率降低50%（RD50）的连三甲苯、均三甲苯和偏三甲苯浓度分别为578、519、541 ppm。与对照组相比，在所有三个测试浓度下，对连三甲苯进行90天的吸入暴露均增加了细胞巨噬细胞、多形核白细胞的总数以及淋巴细胞数量。所有暴露组支气管肺泡灌洗（BAL）中的总蛋白、乳酸脱氢酶（LDH）和酸性磷酸酶活性均显著增加。基于在呼吸道观察到的效应，对于三甲苯异构体的职业暴露，应考虑至少10 ppm的阈限值。
