Wishart H, Sharpe D
University of New Brunswick (Saint John), Montreal, Quebec.
J Clin Exp Neuropsychol. 1997 Dec;19(6):810-24. doi: 10.1080/01688639708403762.
Neuropsychological studies of multiple sclerosis (MS) from a 20-year period were reviewed using meta-analytic and vote-count techniques. Mean effect sizes comparing MS and healthy control groups on variables categorized by neuropsychological domain were small to moderate in magnitude; all were statistically significant (M(r) = .22 (.13) to .46 (.15), rW = .23 to .43, all p < .05). Interhemispheric transfer, general cognitive ability, and learning/memory were more highly related to MS than were visuoperceptual, visuospatial, and visuoconstructional ability, language and conceptual ability (all p < .05); other domains were generally intermediate. Despite previous reports to the contrary, disease subtype was not shown to be consistently related to neuropsychological status independently of other potential explanatory variables. Findings were interpreted with regard to future research and clinical activities involving patients with MS, including selection of tests for brief neuropsychological screening examinations.
运用元分析和投票计数技术，对长达20年的多发性硬化症（MS）神经心理学研究进行了综述。在按神经心理学领域分类的变量上，比较MS组和健康对照组的平均效应量大小为小到中等；所有效应量均具有统计学意义（M(r)=.22(.13)至.46(.15)，rW=.23至.43，所有p<.05）。与视觉感知、视觉空间和视觉构建能力、语言和概念能力相比，半球间传递、一般认知能力和学习/记忆与MS的关联更为紧密（所有p<.05）；其他领域通常处于中间水平。尽管之前有相反的报道，但疾病亚型并未被证明独立于其他潜在解释变量而始终与神经心理学状态相关。针对涉及MS患者的未来研究和临床活动，包括选择用于简短神经心理学筛查检查的测试，对研究结果进行了解读。
