Kadyrova A A, Novokhatskiĭ A S, Ershov F I
Antibiotiki. 1976 Jul;21(7):642-7.
Interferon-inducing and antiviral activity of a synthetic polyribonucleotide, polyaenylic and polyuridylic acid complex (poly A--poly U) was studied comparatively on a model of experimental infection of albino mice caused by Venezuela Horse Encephalomyeliti Viruos (VHEV) using oral and intraperitoneal administration of the complex. It was shown that dm-interferon induction and antiviral effect comparatively high doses of poly A--poly U (Reanal) were required (1 mg/mouse). The highest antiviral effect was observed after a two-fold administration of the drug (24 hours and immediately before infection). It was more evident after intraperitoneal administration of the inductor. The interferon titers in the animal blood serum after intraperitoneal or oral administration of poly A--poly U were almost the same 58=60+/- +/- 18.9 IU50/ml).
在由委内瑞拉马脑脊髓炎病毒（VHEV）引起的白化小鼠实验感染模型上，比较研究了合成多聚核糖核苷酸多聚腺苷酸和多聚尿苷酸复合物（聚A-聚U）通过口服和腹腔注射给药后的干扰素诱导和抗病毒活性。结果表明，需要相对高剂量的聚A-聚U（Reanal，1mg/小鼠）才能产生较高的干扰素诱导和抗病毒效果。在药物两次给药后（感染前24小时和即将感染前）观察到最高的抗病毒效果。腹腔注射诱导剂后效果更明显。腹腔注射或口服聚A-聚U后动物血清中的干扰素滴度几乎相同（58 = 60±18.9IU50/ml）。
