低能质子和氘核使C3H10T1/2细胞失活。
Inactivation of C3H10T1/2 cells by low energy protons and deuterons.
作者信息
Bettega D, Calzolari P, Marchesini R, Noris Chiorda G L, Piazzolla A, Tallone L, Cera F, Cherubini R, Dalla Vecchia M, Favaretto S, Tiveron P
机构信息
Dipartimento di Fisica dell'Università di Milano and INFN Sezione di Milano.
出版信息
Int J Radiat Biol. 1998 Mar;73(3):303-9. doi: 10.1080/095530098142400.
PURPOSE
To determine the RBE-LET relationship for C3H10T1/2 cell inactivation by protons in the LET range 11-33 keV/microm and to compare inactivation frequencies induced in C3H10T1/2 cells by protons and deuterons at two matching LET values in the range 11-20 keV/microm.
MATERIALS AND METHODS
C3H10T1/2 cells were irradiated with protons and deuterons at the radiobiological facility set up at the 7MV Van de Graaff accelerator at the LNL, Legnaro, Padova. Gamma rays from 60Co were used as reference radiation.
RESULTS
Proton RBE values (alpha/alphagamma) for inactivation of C3H10T1/2 cells are constant around a value of 2 between 11 and 20 keV/microm and then rise sharply to reach a value of 4.2+/-1.0 at 33 keV/microm. Deuteron RBE values are 1.7+/-0.4 and 2.2+/-0.6 at LET values of 13 and 18 keV/microm respectively.
CONCLUSIONS
Proton RBE values with C3H10T1/2 cells are significantly larger than unity at LET values as low as 11 keV/microm. No difference in effectiveness for inactivation of C3H10T1/2 has been found between protons and deuterons at two LET values in the range 10-20 keV/microm.
目的
确定在11 - 33 keV/μm线能量转移（LET）范围内质子使C3H10T1/2细胞失活的相对生物学效应（RBE）与LET的关系，并比较在11 - 20 keV/μm范围内两个匹配LET值下质子和氘核诱导C3H10T1/2细胞的失活频率。
材料与方法
在位于帕多瓦省莱尼亚罗市的国家核物理研究所（LNL）的7MV范德格拉夫加速器建立的放射生物学设施中，用质子和氘核照射C3H10T1/2细胞。来自60Co的γ射线用作参考辐射。
结果
使C3H10T1/2细胞失活的质子RBE值（α/αγ）在11至20 keV/μm之间恒定在约2，然后急剧上升，在33 keV/μm时达到4.2±1.0。在LET值为13和18 keV/μm时，氘核的RBE值分别为1.7±0.4和2.2±0.6。
结论
对于C3H10T1/2细胞，在低至11 keV/μm的LET值下，质子RBE值显著大于1。在10 - 20 keV/μm范围内的两个LET值下，未发现质子和氘核在使C3H10T1/2细胞失活的有效性方面存在差异。
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