McPhillips T H, Dinan D, Subramanian K, Samal S K
Department of Biology, La Salle University, Philadelphia, Pennsylvania 19141, USA.
J Virol. 1998 Apr;72(4):3387-9. doi: 10.1128/JVI.72.4.3387-3389.1998.
The effects of protease digestion on the polypeptide composition and on the infectivity of striped bass virus, an aquareovirus, were examined. Both trypsin and chymotrypsin enhanced the infectivity of the virus. Enhancement of infectivity was correlated with the digestion of the outer capsid protein, VP7. These studies support the assertion that VP7 is the outermost capsid protein and suggest that VP4 and VP5 are exposed on the outer surface of infectious particles. The possible role of VP7 in the variation in virulence observed among aquareovirus isolates is discussed.
研究了蛋白酶消化对条纹鲈病毒（一种水生呼肠孤病毒）的多肽组成和感染性的影响。胰蛋白酶和胰凝乳蛋白酶均增强了该病毒的感染性。感染性的增强与外衣壳蛋白VP7的消化有关。这些研究支持了VP7是最外层衣壳蛋白的论断，并表明VP4和VP5暴露在感染性颗粒的外表面。文中还讨论了VP7在水生呼肠孤病毒分离株间观察到的毒力变化中可能发挥的作用。
