[三环类抗抑郁药与大鼠外周制剂中去甲肾上腺素和5-羟色胺的相互作用]
[Interaction of tricyclic antidepressants with noradrenaline and 5-hydroxytryptamine in peripheral preparations of the rat].
作者信息
Van Dorsser W, Dresse A
出版信息
Arch Int Pharmacodyn Ther. 1976 Mar;220(1):164-76.
The potentiation of the noradrenaline (NA) actions by antidepressant drugs was studied in vitro on the rat vas deferens and in vivo on the rat blood pressure. A new dibenzazepine compound, LM 208, and two antiparkinsonian drugs, orphenadrine and its demethylated derivative, were compared to well known antidepressants. The modification by all these agents of the rat uterus response to 5-hydroxytryptamine (5-HT) was also investigated. The possible use of these interactions as models for NA and 5-HT uptake inhibition is discussed.
在体外对大鼠输精管以及在体内对大鼠血压进行了研究，以探讨抗抑郁药物对去甲肾上腺素（NA）作用的增强效果。将一种新型二苯氮䓬化合物LM 208以及两种抗帕金森病药物——奥芬那君及其去甲基衍生物，与知名抗抑郁药物进行了比较。还研究了所有这些药物对大鼠子宫对5-羟色胺（5-HT）反应的影响。讨论了将这些相互作用用作NA和5-HT摄取抑制模型的可能性。
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