Ibrahim M A, Emerson J F, Cotman C W
Institute for Brain Aging and Dementia, University of California and Irvine, 92697-4540, USA.
Invest Radiol. 1998 Mar;33(3):153-62. doi: 10.1097/00004424-199803000-00005.
This study was conducted to prove the feasibility of using cerebrospinal fluid (CSF) T1 and T2 measurements to assess the blood-brain barrier integrity in disease states not noted for focal blood-brain barrier disruption, such as Alzheimer's disease.
T1 and T2 of human CSF samples were measured with and without gadolinium Gd-DTPA over a concentration range of 1.98 x 10(-3) to 6.32 mM, in a GE 1.5-T Signa scanner.
T1 and T2 of human CSF without Gd-DTPA were measured as 2.39 and 0.23 s. K1 and K2 were calculated as 6.25 and 6.74 mM(-1) s(-1). The lowest Gd-DTPA concentration with measurable T1 and T2 was 1.98 x 10(-3) mM. There is no statistically significant difference in T2 and K2 at different repetition times.
This work demonstrates that a single measurement of relaxation times after contrast-enhanced magnetic resonance imaging could be used to determine the Gd-DTPA concentration in CSF. It may thus be feasible, using this technique, to measure intersubject and intraregional variability in the quantity of Gd-DTPA transferred across the blood-brain barrier after intravenous injection of contrast agent.
本研究旨在证明在诸如阿尔茨海默病等无局灶性血脑屏障破坏的疾病状态下，利用脑脊液（CSF）的T1和T2测量来评估血脑屏障完整性的可行性。
在GE 1.5-T Signa扫描仪中，对浓度范围为1.98×10⁻³至6.32 mM的人CSF样本，在有和没有钆喷酸葡胺（Gd-DTPA）的情况下测量其T1和T2。
未加Gd-DTPA的人CSF的T1和T2测量值分别为2.39秒和0.23秒。K1和K2计算值分别为6.25和6.74 mM⁻¹ s⁻¹。可测量T1和T2的最低Gd-DTPA浓度为1.98×10⁻³ mM。不同重复时间下的T2和K2无统计学显著差异。
这项工作表明，对比增强磁共振成像后单次测量弛豫时间可用于确定CSF中的Gd-DTPA浓度。因此，利用该技术测量静脉注射造影剂后跨血脑屏障转移的Gd-DTPA量在个体间和区域内的变异性可能是可行的。
