Chassaing C, Duchene-Marullaz P
Arch Int Pharmacodyn Ther. 1976 Mar;220(1):45-50.
The effects of meprobamate on heart rate in the unanesthetized dog were compared under two experimental conditions: (1) In the animal equipped with a telemetry device, in which the heart rate was on average 70/min over a 24 hour period, i.v. injection of 20 mg/kg of meprobamate tended to increase heart rate, a dose of 50 mg/kg provoking a significant tachycardia; (2) In the untrained dog restrained on a table, in which the heart rate ranged from 100 to 110/min, i.v. doses of 20 and 30 mg/kg of meprobamate did not lower heart rate, notwithstanding a significant sedative effect whereas a dose of 50 mg/kg provoked tachycardia; atropine-induced cardio-acceleration was not influenced by these doses of meprobamate.
（1）在配备遥测装置的动物中，其心率在24小时内平均为70次/分钟，静脉注射20毫克/千克眠尔通往往会使心率增加，50毫克/千克的剂量会引起显著的心动过速；（2）在限制在实验台上的未经训练的犬中，其心率范围为100至110次/分钟，静脉注射20和30毫克/千克眠尔通不会降低心率，尽管有显著的镇静作用，而50毫克/千克的剂量会引起心动过速；这些剂量的眠尔通不影响阿托品引起的心动加速。
