Gliński B, Dymek P, Skołyszewski J
Department of Radiation Oncology of Maria Skłodowska-Curie Memorial Center, Kraków, Poland.
J Neurooncol. 1998 Jan;36(2):159-65. doi: 10.1023/a:1005760123991.
Results of altered therapy schedules obtained in postoperative treatment of 294 patients with malignant gliomas over last 20 years are presented. During this period 135 patients received Conventional Irradiation and Chemotherapy (CICH), 61 patients received Conventional Irradiation (CI), 59 patients received Split Course High Fractional Dose Irradiation (SCHFDI), and 39 patients received Twice a Day Accelerated Irradiation (TDAI). Actuarial survival rates at 2, 3 and 5 years were 19%, 7%, 0% respectively for patients treated with CICH, and they were 21%, 10%, 0% for CI group, 24%, 12%, 0% for SCHFDI option and 15%, 8%, 0% for TDAI schedule. According to the Cox proportional hazard model, only age was significant factor in prognosis.
本文呈现了过去20年中294例恶性胶质瘤患者术后治疗采用不同治疗方案的结果。在此期间，135例患者接受了常规放疗和化疗（CICH），61例患者接受了常规放疗（CI），59例患者接受了分割疗程高剂量放疗（SCHFDI），39例患者接受了每日两次加速放疗（TDAI）。接受CICH治疗的患者2年、3年和5年的精算生存率分别为19%、7%、0%，CI组为21%、10%、0%，SCHFDI方案组为24%、12%、0%，TDAI方案组为15%、8%、0%。根据Cox比例风险模型，仅年龄是预后的显著因素。
