Gliński B
Department of Radiation Oncology of Maria Sklodowska-Curie Memorial Center, Kraków, Poland.
J Neurooncol. 1993 May;16(2):167-72. doi: 10.1007/BF01324704.
A prospective randomized study of 108 patients with cerebral malignant gliomas was carried out at the Department of Radiation Oncology of Maria Sklodowska-Curie Memorial Center in Kraków. 44 patients with histologically proven glioblastoma multiforme and 64 patients with anaplastic astrocytoma received postoperative radiotherapy. Patients were randomized to two treatment arms: Conventionally Fractionated Radiotherapy (CFR) and Hypofractionated Radiotherapy (HF). In the CFR group, the whole brain was irradiated to the total dose of 50 Gy in 25 fractions over 5 weeks, then a 10 Gy 'boost' in 5 fractions in 5 days was delivered to the site of the primary lesion. In the HF group, there were 3 courses of irradiation separated by a one month interval. In each of the two first series the patients received 20 Gy in 5 fractions in 5 days to the whole brain, and in the third course, 10 Gy 'boost' in 5 days was delivered as in the CFR regimen. The tolerance to treatment has been found to be good in both groups. The 2-year actuarial survival rate for patients with anaplastic astrocytoma was 22% for CFR and 18% for HF. Patients with glioblastoma multiforme treated with HF had a better prognosis in comparison to the CFR group with the two-year actuarial survival rates being 23% and 10%, respectively. This difference is statistically significant at the 0.05 level.
在克拉科夫的玛丽亚·斯克洛多夫斯卡-居里纪念中心放射肿瘤学系，对108例脑恶性胶质瘤患者进行了一项前瞻性随机研究。44例经组织学证实为多形性胶质母细胞瘤的患者和64例间变性星形细胞瘤患者接受了术后放疗。患者被随机分为两个治疗组：常规分割放疗（CFR）组和大分割放疗（HF）组。在CFR组中，全脑在5周内分25次照射，总剂量为50 Gy，然后在5天内分5次给予10 Gy的“推量”照射至原发灶部位。在HF组中，进行3个疗程的照射，间隔1个月。在最初两个疗程的每个疗程中，患者全脑在5天内分5次接受20 Gy照射，在第三个疗程中，与CFR方案一样，在5天内给予10 Gy的“推量”照射。结果发现两组患者对治疗的耐受性都很好。间变性星形细胞瘤患者的2年精算生存率，CFR组为22%，HF组为18%。接受HF治疗的多形性胶质母细胞瘤患者与CFR组相比预后更好，2年精算生存率分别为23%和10%。在0.05水平上，这种差异具有统计学意义。
