异丙肾上腺素对山羊泌尿功能的影响。
Effect of isoproterenol on urinary function in goats.
作者信息
Vandeputte-Van Messom G, Peeters G
出版信息
Arch Int Pharmacodyn Ther. 1976 Apr;220(2):346-7.
PMID:952590
Abstract
Intraventricular administration of small doses (6.3-19-58 ng/kg/min) of isoproterenol (ISO) in non-hydrated goats produced a diuretic response, a decrease in urinary Na+, K+ and Cl- excretion and an increase in free water clearance. The diuretic response of ISO could be blocked by propranolol, but not by phentolamine. The data suggest that hypothalamic beta-adrenoceptors are involved in the inhibition of ADH release.
摘要
在未补水的山羊体内，脑室内注射小剂量（6.3 - 19.58纳克/千克/分钟）的异丙肾上腺素（ISO）会产生利尿反应，使尿钠、钾和氯的排泄减少，自由水清除率增加。ISO的利尿反应可被普萘洛尔阻断，但不能被酚妥拉明阻断。这些数据表明，下丘脑β - 肾上腺素能受体参与了抗利尿激素释放的抑制过程。
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