Effect of isoproterenol on urinary function in goats.

Intraventricular administration of small doses (6.3-19-58 ng/kg/min) of isoproterenol (ISO) in non-hydrated goats produced a diuretic response, a decrease in urinary Na+, K+ and Cl- excretion and an increase in free water clearance. The diuretic response of ISO could be blocked by propranolol, but not by phentolamine. The data suggest that hypothalamic beta-adrenoceptors are involved in the inhibition of ADH release.