Antidiuretic effects of intracerebroventricular infusion of adrenaline in conscious goats.

The effects of adrenaline (A) upon waterdiuresis were studied in conscious, hydrated goats, provided with a permanent cannula into the 3rd ventricle. Adrenaline induced a reduction in urinary volume and in free water clearance and a rise in the osmolality of the urine. These effects were dose-dependent and significant. A biphasic Cl-excretion pattern, consisting op of an initial fall below control level and a subsequent increase was observed. Na+ and K+ excretion rates were reduced. Central pretreatment with phentolamine completely antagonized the antidiuretic action of A. Propranolol, atropine and hexamethonium were ineffective. Alpha-adrenoceptors might be involved in vasopressin release.