内皮素转化酶：其功能方面
Endothelin-converting enzyme: its functional aspect.
作者信息
Gomazkov O A
机构信息
Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, ul. Pogodinskaya 10, Moscow, 119832 Russia.
出版信息
Biochemistry (Mosc). 1998 Feb;63(2):125-32.
The system of endothelin peptides and their structure, biological activity, and role in physiological and pathological processes are reviewed with emphasis on endothelin-converting enzyme (ECE), which catalyzes the terminal processing of endothelin. Molecular specificity, structure, isoforms, physicochemical characteristics, substrate preference, and tissue localization characterize this enzyme as a novel and highly important metalloendopeptidase. The role of ECE in pathological processes and data on inhibitors of the enzyme which can have medical implication are summarized.
本文综述了内皮素肽系统及其结构、生物活性以及在生理和病理过程中的作用，重点介绍了催化内皮素末端加工的内皮素转化酶（ECE）。该酶的分子特异性、结构、同工型、理化特性、底物偏好和组织定位表明它是一种新型且极其重要的金属内肽酶。本文总结了ECE在病理过程中的作用以及具有医学意义的该酶抑制剂的数据。
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