Nakayama K, Nakagawa T, Hiyama T, Katsu H, Wakutsu N, Koga M, Usijima S
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.
Int J Clin Pharmacol Res. 1997;17(4):155-64.
The biological rhythm of females is closely related to the menstrual cycle, and this rhythm is believed to influence circadian changes in body temperature. This study investigated and compared the patterns of circadian changes in the body temperature of healthy adult females and patients suffering from premenstrual syndrome or major depression. Body temperature was measured both rectally and sublingually in healthy subjects, and only sublingually in the patients. During the luteal phase in healthy adult females, both the average and lowest nocturnal body temperatures increased, the amplitude of the circadian changes decreased, and the times of the lowest and highest temperatures within a 24-hour period were delayed by 2-3 h. In the patients, the amplitude decreased during disease periods, especially in the follicular phase, whereas in the luteal phase, circadian changes showed great variation each day, although the decrease in amplitude was not as remarkable. The results show that (i) the biological rhythm of females is intrinsically unstable in the luteal phase, although this rhythm is stable in the follicular phase; and, (ii) symptoms were often aggravated with the decreases in amplitude experienced in the luteal phase.
女性的生物节律与月经周期密切相关，并且这种节律被认为会影响体温的昼夜变化。本研究调查并比较了健康成年女性以及患有经前综合征或重度抑郁症患者的体温昼夜变化模式。在健康受试者中，通过直肠和舌下两种方式测量体温，而在患者中仅通过舌下测量体温。在健康成年女性的黄体期，夜间平均体温和最低体温均升高，昼夜变化幅度减小，并且在24小时内最低体温和最高体温出现的时间延迟2 - 3小时。在患者中，在疾病发作期幅度减小，尤其是在卵泡期，而在黄体期，尽管幅度减小并不显著，但昼夜变化每天都有很大差异。结果表明：（i）女性的生物节律在黄体期本质上不稳定，尽管在卵泡期这种节律是稳定的；并且，（ii）症状通常会随着黄体期幅度的减小而加重。
