Sheth T, Nargundkar M, Chagani K, Anand S, Nair C, Yusuf S
Preventive Cardiology and Therapeutics Programme, Hamilton Civic Hospitals Research Centre, McMaster University, Hamilton, Ontario, Canada.
Ethn Health. 1997 Nov;2(4):287-95. doi: 10.1080/13557858.1997.9961837.
The study of ethnic differences in disease is a methodological challenge as ethnicity is often not identified in existing datasets and surrogate measures need to be used. We have developed a novel methodology combining last name and country of birth to study mortality patterns of Canadians of South Asian (SA) and Chinese (CH) ethnic origin and have compared death rates among SA, CH, and White (WH) Canadians.
SA and CH were identified in the Canadian Mortality Data Base (CMDB) using the last name and country of birth of the deceased. Records of people who had been born in countries with large South Asian and Chinese populations (e.g. India, Pakistan, China, Hong Kong) were selected and manually screened by last name. A name directory was then created of distinct South Asian and Chinese names and this directory was used to search all other records in the CMDB for SA and CH deaths. Where necessary, other identifying characteristics such as first name and parents' last name were also used. Population counts were obtained from the Census self-reported question on ethnicity for SA and CH. WH were identified as non-immigrant Canadians who were neither SA nor CH. The method of assigning ethnicity in the CMDB and Census were assessed for comparability and issues of validity and reliability were addressed.
Using this method, 10,989 SA and 21,548 CH deaths were identified. There was marked heterogeneity in birthplace, with only 56% of SA born in South Asia and only 74% of CH born in Greater China. Last names had high validity for self-reported ethnicity in a population sample of SA and were highly reproducible. Mortality rates varied dramatically between groups studied. SA and WH had high rates of ischemic heart disease while stroke mortality was similar among all three groups. Cancer death rates were high in CH and WH and much lower in SA.
Last names and country of birth can be used to determined ethnicity of SA and CH with validity and reliability, and leads to a more accurate classification than country of birth alone. The contrasting patterns observed in mortality from major causes of death suggest many interesting hypotheses for further study.
疾病中的种族差异研究是一项方法学挑战,因为现有数据集中往往未明确种族,需要使用替代指标。我们开发了一种将姓氏和出生地相结合的新方法,以研究南亚(SA)和华裔(CH)加拿大人群的死亡率模式,并比较了SA、CH和白人(WH)加拿大人的死亡率。
在加拿大死亡率数据库(CMDB)中,利用死者的姓氏和出生地来识别SA和CH。选择那些出生在南亚和中国人口众多的国家(如印度、巴基斯坦、中国、香港)的人的记录,并按姓氏进行人工筛选。然后创建了一个包含不同南亚和中国姓氏的名录,并使用该名录在CMDB中搜索所有其他SA和CH死亡记录。必要时还使用了其他识别特征,如名字和父母的姓氏。SA和CH的人口计数来自人口普查中关于种族的自我报告问题。WH被确定为既非SA也非CH的非移民加拿大人。评估了CMDB和人口普查中种族分配方法的可比性,并解决了有效性和可靠性问题。
使用该方法,识别出10989例SA死亡和21548例CH死亡。出生地存在显著异质性,只有56%的SA出生在南亚,只有74%的CH出生在大中华地区。在SA人群样本中,姓氏对自我报告的种族具有较高的有效性且高度可重复。所研究的组间死亡率差异很大。SA和WH的缺血性心脏病发病率较高,而三组中风死亡率相似。CH和WH的癌症死亡率较高,SA则低得多。
姓氏和出生地可用于有效且可靠地确定SA和CH的种族,比仅使用出生地能得出更准确的分类。在主要死因死亡率中观察到的对比模式提出了许多有趣的进一步研究假设。