Boonen S, Pelemans W, Broos P
Afdeling Geriatrie, Universitaire Ziekenhuizen K.U. Leuven.
Tijdschr Gerontol Geriatr. 1997 Aug;28(4):172-7.
Age-related fractures are considered to be primarily the consequence of bone loss and increased bone fragility. In line with this dominant view on fracture etiology, prevention studies have primarily focused on pharmacologic interventions to increase bone density of the femoral neck. However, osteoporotic fracture occurrence is not entirely accounted for by bone strength but also related to the incidence and impact of falls. Recent data have provided evidence that an intensive multifactorial intervention strategy can be used to decrease the incidence of falls, but it remains to be determined whether fall prevention can be used successfully to prevent fall-related injuries or hip fracture. In fact, while more than 90% of hip fractures involve falls, hip fracture occurs in only about 1% of falls, suggesting that falls that cause hip fracture may differ qualitatively from other falls. These differences relate to the biomechanical aspects of falls, i.e., the energy that is ultimately transmitted to the proximal femur. Fall severity, rather than fall initiation, may therefore have to be the primary subject of future research.
与年龄相关的骨折被认为主要是骨质流失和骨脆性增加的结果。根据这种关于骨折病因的主流观点,预防研究主要集中在通过药物干预来增加股骨颈的骨密度。然而,骨质疏松性骨折的发生并非完全由骨强度决定,还与跌倒的发生率和影响有关。最近的数据表明,强化多因素干预策略可用于降低跌倒发生率,但跌倒预防能否成功用于预防与跌倒相关的损伤或髋部骨折仍有待确定。事实上,虽然超过90%的髋部骨折与跌倒有关,但只有约1%的跌倒会导致髋部骨折,这表明导致髋部骨折的跌倒在性质上可能与其他跌倒不同。这些差异与跌倒的生物力学方面有关,即最终传递到股骨近端的能量。因此,跌倒的严重程度而非跌倒的起始因素可能必须成为未来研究的主要课题。