Tavassoli S, Yamalik N, Caglayan F, Caglayan G, Eratalay K
Department of Periodontology, Faculty of Dentistry, University of Hacettepe, Ankara, Turkey.
J Periodontol. 1998 Feb;69(2):108-12. doi: 10.1902/jop.1998.69.2.108.
The present study was conducted to determine the clinical effects of nifedipine on the gingiva of 97 patients. Patients were examined for changes in periodontal status and divided into subgroups, based on their age, gender, duration of drug intake, presence/absence of plaque and gingival inflammation, and according to the presence and severity of gingival overgrowth. Gingival overgrowth was noticed in 29% of the patients. Among the recorded parameters, duration of drug intake, presence/severity of gingival inflammation, and gender seemed to have the greatest effect on the development of gingival overgrowth. Patients with higher gingival inflammation scores, those on nifedipine medication for more than 4 years, and males were likely to have an increased tendency for higher incidence and severity of gingival overgrowth. The findings of the present study suggest that nifedipine medication induces gingival overgrowth and that certain local factors are involved in the pathogenesis of drug-induced gingival overgrowth. However, individual ability and sensitivity to metabolize the drug and its metabolites also seem to be important etiological factors.
本研究旨在确定硝苯地平对97例患者牙龈的临床影响。对患者的牙周状况变化进行检查，并根据年龄、性别、服药时长、是否存在菌斑和牙龈炎症以及牙龈增生的存在情况和严重程度将患者分为亚组。29%的患者出现了牙龈增生。在记录的参数中，服药时长、牙龈炎症的存在/严重程度以及性别似乎对牙龈增生的发展影响最大。牙龈炎症评分较高的患者、服用硝苯地平超过4年的患者以及男性，牙龈增生的发生率和严重程度增加的可能性更大。本研究结果表明，服用硝苯地平会导致牙龈增生，并且某些局部因素参与了药物性牙龈增生的发病机制。然而，个体代谢药物及其代谢产物的能力和敏感性似乎也是重要的病因因素。
