Wiseman L L, Senn J S, Miller R G, Price G B
Br J Cancer. 1976 Jul;34(1):46-52. doi: 10.1038/bjc.1976.120.
Human bone marrow obtained from patients with neutropenia contains a cell population which is absent or diminished in normal marrow. The abnormal population is composed of cells of volume 200-300 mum3 which sediment at 5-5 to 8-5 mm/h. Normal marrow contains one cell class giving rise to increased numbers of grnaulocyte colonies after mass culture, while marrow obtained from neutropenic patients, or from patients with marrow regeneration, shows two such populations; one of these cell classes corresponds to the abnormally large cells demonstrated on velocity sedimentation analysis. This population of large cells may represent a group of either self-renewing cells related to the committed granulocyte progenitors or the pluripotent stem cell.
从中性粒细胞减少症患者获取的人骨髓含有一个在正常骨髓中不存在或数量减少的细胞群体。异常群体由体积为200 - 300立方微米的细胞组成，这些细胞以5.5至8.5毫米/小时的速度沉降。正常骨髓含有一类细胞，在大量培养后可产生数量增加的粒细胞集落，而从中性粒细胞减少症患者或骨髓再生患者获取的骨髓则显示有两类这样的细胞群体；其中一类细胞群体与速度沉降分析中显示的异常大细胞相对应。这群大细胞可能代表一组与定向粒细胞祖细胞相关的自我更新细胞或多能干细胞。
