Senn J S, Lai C C, Price G B
Br J Cancer. 1980 Jan;41(1):40-6. doi: 10.1038/bjc.1980.5.
Levamisole, which has immunostimulant activity, is now being used to treat some forms of cancer. We report that the drug enhances granulocyte colony formation. The mechanism of action appears to be partly through modulation of molecules on cell membranes. The molecular content of colony-stimulating activity (CSA) released into leucocyte-conditioned medium by cells of leukaemic and some preleukaemic patients can be quantitatively altered by levamisole, both in vitro and in vivo, but the CSA produced is qualitatively similar to that released by normal cells. The demonstrated levamisole enhancement of colony formation, and altered CSA types detected in leucocyte-conditioned medium, makes this drug a promising candidate for treatment of selected leukaemic states and in preleukaemia.
具有免疫刺激活性的左旋咪唑目前正用于治疗某些类型的癌症。我们报告该药物可增强粒细胞集落形成。其作用机制似乎部分是通过调节细胞膜上的分子。左旋咪唑在体外和体内均可定量改变白血病患者及部分白血病前期患者细胞释放到白细胞条件培养基中的集落刺激活性（CSA）的分子含量，但所产生的CSA在质量上与正常细胞释放的相似。已证实的左旋咪唑对集落形成的增强作用以及在白细胞条件培养基中检测到的CSA类型的改变，使该药物成为治疗特定白血病状态和白血病前期的有前景的候选药物。
