Trichopoulos D, Papaevangelou G, Violaki M, Vissoulis C, Sparros L, Manousos O N
Br J Cancer. 1976 Jul;34(1):83-7. doi: 10.1038/bjc.1976.125.
Average annual age-adjusted mortality rates per 100,000 from primary hepatic carcinoma (PHC) among males for 1971-1973 in the urban and rural areas of the 9 geographical regions of Greece were estimated. Hepatitis-B surface antigen (HBsAg) prevalence by region and area was evaluated in a sample of 22,844 Greek Air Force recruits from all parts of the country. Mortality from PHC was found significantly higher in urban areas (28-30 vs. 18-81) whereas prevalence of HBsAg was higher in rural areas (5-3% vs. 3-90%). Nevertheless further statistical analysis showed that there is a strong correlation between HBsAg prevalence and mortality from PHC, which is higher in rural (r = + 0-88) than in urban (+ 0-57) areas. The latter findings indicate that hepatitis B infection and PHC may be causally related.
估算了1971 - 1973年希腊9个地理区域城乡男性原发性肝癌（PHC）每10万人年年龄调整死亡率。在来自该国各地的22844名希腊空军新兵样本中，评估了各地区和区域的乙肝表面抗原（HBsAg）流行率。发现城市地区PHC死亡率显著更高（28 - 30对18 - 81），而农村地区HBsAg流行率更高（5 - 3%对3 - 90%）。然而，进一步的统计分析表明，HBsAg流行率与PHC死亡率之间存在强相关性，农村地区（r = + 0 - 88）比城市地区（+ 0 - 57）更高。后一发现表明乙肝感染与PHC可能存在因果关系。
