Chacín B, Corzo G, Montiel M
Instituto de Medicina del Trabajo e Higiene Industrial, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Invest Clin. 1997 Dec;38(4):171-90.
In order to evaluate the respiratory health status in workers exposed to antigenic substances (chicken feathers, serum and dropping), typical of usual practice in the avian slaughter-house, pulmonary function was studied on 49 exposed workers, and in a sample of 49 people with similar anthropometric characteristics, non exposed to these substances, by means of occupational-medical history, spirometric tests, hematologic and biochemical tests, and postero-anterior chest x-rays. The values for the spirometric parameters varied with sex, age, weight, size, smoking habits, length of employment and exposure time, and there were no significant differences between exposed and control groups as a whole; showing significant differences with decreasing values for CVF, VEF1, PFE, FEF-25% and FEF-50% in the intermediate zone workers, and in subjects with short exposure time (< 1 year). Prevalence of clinical findings in the exposed population was significantly higher than the non exposed group (p < 0.001). Laboratory tests showed reduction of monocytes cells in the exposed group (p < 0.05) in addition, in the exposed women there was an increase of the eosinophiles, total proteins and globulines (p < 0.05). The frequency of radiographic findings was significantly higher in the exposed group (p < 0.006), and they were no specific. The lack of association between clinical findings, laboratory and radiographic findings, with the spirometric results, could be explained by the short period of exposure, individual and collectives hygienic conditions and size of the sample.
为了评估禽类屠宰场常见的接触抗原性物质(鸡毛、血清和粪便)的工人的呼吸健康状况,我们对49名接触工人以及49名具有相似人体测量特征、未接触这些物质的人进行了肺功能研究,研究方法包括职业医学史、肺量计测试、血液学和生化测试以及后前位胸部X光检查。肺量计参数值随性别、年龄、体重、体型、吸烟习惯、就业时长和接触时间而变化,总体而言,接触组和对照组之间没有显著差异;但中间区域的工人以及接触时间短(<1年)的受试者的CVF、VEF1、PFE、FEF-25%和FEF-50%值呈下降趋势,存在显著差异。接触人群中临床症状的患病率显著高于未接触组(p<0.001)。实验室测试显示,接触组的单核细胞减少(p<0.05),此外,接触组女性的嗜酸性粒细胞、总蛋白和球蛋白增加(p<0.05)。接触组的影像学检查结果频率显著更高(p<0.006),且无特异性。临床症状、实验室检查和影像学检查结果与肺量计结果之间缺乏关联,这可能是由于接触时间短、个人和集体卫生条件以及样本量等原因导致的。