Corzo G, Naveda R
Instituto de Medicina del Trabajo e Higiene Industrial, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Invest Clin. 1998 Sep;39(3):175-87.
In order to determine both clinical and spirometric changes due to high environmental concentrations of wheat dust at a wheat processing plant mill, 48 exposed men and 48 age and antroprometrically-matched, non-exposed apparently healthy men were studied. In both groups a medical and occupational history were taken, and spirometric measurements were carried out, that included Forced Vital Capacity (FVC), Forced Expiratory Volume at the first second (FEV1), Peak Flow Rate (PFR), Forced Percentual Expiratory Volume (FEV%), Forced Percentual Vital Capacity (FVC%), Forced Expiratory Flow at 25% (FEV25%), at 50% (FEV50%) and at 75% (FEV75%) of their Forced Vital Capacity, which were analyzed through Corzo's predictive equations and the lung deterioration's criteria by USA's Thoracic Association. The environmental wheat dust was determined by gravimetry and its concentration was higher than the legally admitted (3/5, 60%). There was a decrease in the PFR, FEV%, FEV25% and FEV75%. (p < 0.05). In addition, 4 restrictive and 1 obstructive syndrome were detected in the exposed workers and none in the control group. The spirometric values diminished in a positive correlation with the time of exposure and smoking habits. There was no correlation between the clinical findings and the dust concentration but it did exist with the spirometric values. It is concluded that in this plant, the wheat dust exposed workers have a diminished spirometric values.
为了确定小麦加工厂环境中高浓度小麦粉尘所导致的临床和肺功能变化,对48名暴露男性以及48名年龄和人体测量学指标匹配的、未暴露的明显健康男性进行了研究。两组人员均进行了医学和职业史调查,并进行了肺功能测量,包括用力肺活量(FVC)、第1秒用力呼气量(FEV1)、峰值流速(PFR)、用力呼气百分比(FEV%)、用力肺活量百分比(FVC%)、用力肺活量25%时的呼气流量(FEV25%)、50%时的呼气流量(FEV50%)和75%时的呼气流量(FEV75%),这些指标通过科尔佐的预测方程以及美国胸科学会的肺功能恶化标准进行分析。环境中的小麦粉尘通过重量法测定,其浓度高于法定允许浓度(3/5,60%)。PFR、FEV%、FEV25%和FEV75%均有所下降(p < 0.05)。此外,在暴露工人中检测到4例限制性综合征和1例阻塞性综合征,而对照组未检测到。肺功能值的下降与暴露时间和吸烟习惯呈正相关。临床发现与粉尘浓度之间无相关性,但与肺功能值存在相关性。得出的结论是,在该工厂中,暴露于小麦粉尘的工人肺功能值下降。