Weller H N, Young M G, Michalczyk S J, Reitnauer G H, Cooley R S, Rahn P C, Loyd D J, Fiore D, Fischman S J
Combinatorial Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
Mol Divers. 1997;3(1):61-70. doi: 10.1023/a:1009636725336.
Rapid reverse-phase analytical and preparative HPLC methods have been developed for application to parallel synthesis libraries. Gradient methods, short columns, and high flow rates allow analysis of over 300 compounds per day on a single system, or purification of up to 200 compounds per day on a single preparative system. Hardware and software modifications allow continuous unattended use for maximum efficiency and throughput.
已经开发出快速反相分析型和制备型高效液相色谱方法，用于平行合成文库。梯度方法、短柱和高流速使得在单个系统上每天能够分析300多种化合物，或者在单个制备系统上每天能够纯化多达200种化合物。硬件和软件的改进使得能够连续无人值守使用，以实现最高效率和通量。
