Taylor G W, Burt B A, Becker M P, Genco R J, Shlossman M, Knowler W C, Pettitt D J
School of Dentistry, University of Michigan, Ann Arbor 48109, USA.
J Periodontol. 1998 Jan;69(1):76-83. doi: 10.1902/jop.1998.69.1.76.
This study tested the hypothesis that persons with non-insulin dependent diabetes mellitus (NIDDM) have greater risk of more severe alveolar bone loss progression over a 2-year period than those without NIDDM. Data from the longitudinal study of the oral health of residents of the Gila River Indian Community were analyzed for 362 subjects, aged 15 to 57, 338 of whom had less than 25% radiographic bone loss at baseline, and who did not develop NIDDM nor lose any teeth during the 2-year study period. The other 24 subjects had NIDDM at baseline, but met the other selection criteria. Bone scores (scale 0-4) from panoramic radiographs corresponded to bone loss of 0%, 1%-24%, 25%-49%, 50%-74%, or 75% and greater. Change in bone score category was computed as the change in worst bone score (WBS) reading after 2 years. Age, calculus, NIDDM status, time to follow-up examination, and baseline WBS were explanatory variables in regression models for ordinal categorical response variables. NIDDM was positively associated with the probability of a change in bone score when the covariates were controlled. The cumulative odds ratio for NIDDM at each threshold of the ordered response was 4.23 (95% C.I. = 1.80, 9.92). In addition to being associated with the incidence of alveolar bone loss (as demonstrated in previous studies), these results suggest an NIDDM-associated increased rate of alveolar bone loss progression.
在两年时间里，非胰岛素依赖型糖尿病（NIDDM）患者比无NIDDM的患者发生更严重牙槽骨丧失进展的风险更高。对吉拉河印第安社区居民口腔健康纵向研究的数据进行了分析，研究对象为362名年龄在15至57岁之间的受试者，其中338人在基线时影像学骨丧失小于25%，且在两年研究期间未患NIDDM，也未掉牙。另外24名受试者在基线时患有NIDDM，但符合其他入选标准。全景X线片的骨评分（0 - 4分）分别对应0%、1% - 24%、25% - 49%、50% - 74%或75%及以上的骨丧失。骨评分类别的变化计算为两年后最差骨评分（WBS）读数的变化。年龄、牙石、NIDDM状态、随访检查时间和基线WBS是有序分类反应变量回归模型中的解释变量。在控制协变量时，NIDDM与骨评分变化的概率呈正相关。在有序反应的每个阈值下，NIDDM的累积比值比为4.23（95%置信区间 = 1.80, 9.92）。这些结果表明，除了与牙槽骨丧失的发生率相关（如先前研究所示）外，NIDDM还与牙槽骨丧失进展速度加快有关。
