Dithmar S, Holz F G, Völcker H E
Universitäts-Augenklinik Heidelberg.
Klin Monbl Augenheilkd. 1997 Nov;211(5):338-41. doi: 10.1055/s-2008-1035144.
Massive retinal gliosis is a rare, extreme form of a reactive glial cell proliferation and can cause difficulties in the differential diagnosis of intraocular tumors.
A 33-year-old patient presented with a painful neovascular glaucoma and a solid intraocular mass. The left globe was subsequently enucleated. The fundus could not be visualized due to lens opacities and an incomplete occlusive membrane. The findings of the magnetic resonance imaging were compatible with an intraocular malignant choroidal melanoma.
Histologically the intraocular tumor proved to be a massive retinal gliosis replacing all retinal layers. Immunohistological reactions were positive for GFAP ("glial fibrillary acidic protein"). There were many dilated vessels within the glial mass.
Massive proliferations of glial cells represent secondary changes which are usually found in blind eyes with various underlying diseases. They can be confused with other intraocular tumors, particularly if the fundus cannot be visualized. Ultrasound-reflectivity and magnet resonance imaging findings of massive retinal gliosis may resemble a malignant choroidal melanoma.
大量视网膜胶质增生是一种罕见的、反应性胶质细胞增殖的极端形式，可导致眼内肿瘤鉴别诊断困难。
一名33岁患者出现疼痛性新生血管性青光眼和眼内实性肿物。随后摘除了左眼眼球。由于晶状体混浊和不完全闭塞膜，无法观察到眼底。磁共振成像结果与眼内恶性脉络膜黑色素瘤相符。
组织学检查显示眼内肿瘤为大量视网膜胶质增生，取代了所有视网膜层。免疫组织学反应对胶质纤维酸性蛋白（GFAP）呈阳性。胶质团块内有许多扩张的血管。
胶质细胞的大量增殖代表继发性改变，通常见于患有各种基础疾病的盲眼中。它们可能与其他眼内肿瘤混淆，特别是在无法观察到眼底的情况下。大量视网膜胶质增生的超声反射率和磁共振成像表现可能类似于恶性脉络膜黑色素瘤。
