丙磺舒和西咪替丁对大鼠体内氧氟沙星肾排泄的影响。
Effects of probenecid and cimetidine on renal disposition of ofloxacin in rats.
作者信息
Foote E F, Halstenson C E
机构信息
Department of Medicine, Hennepin County Medical Center, and College of Pharmacy, University of Minnesota, Minneapolis 55455, USA.
出版信息
Antimicrob Agents Chemother. 1998 Feb;42(2):456-8. doi: 10.1128/AAC.42.2.456.
Abstract
The renal handling of ofloxacin in rats which were given ofloxacin either alone or in combination with probenecid or cimetidine was studied. In the presence of cimetidine or probenecid, ofloxacin's total and renal clearances were reduced and its half-life was prolonged. This suggests that ofloxacin is secreted by both the anionic and cationic transport systems.
摘要
研究了单独给予大鼠氧氟沙星以及氧氟沙星与丙磺舒或西咪替丁联合给药时大鼠对氧氟沙星的肾脏处理情况。在西咪替丁或丙磺舒存在的情况下，氧氟沙星的总清除率和肾脏清除率降低，半衰期延长。这表明氧氟沙星是通过阴离子和阳离子转运系统分泌的。
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