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Disseminated Mycobacterium avium complex disease in the Swiss HIV Cohort Study: increasing incidence, unchanged prognosis.瑞士HIV队列研究中的播散性鸟分枝杆菌复合群疾病：发病率上升，预后未变。
AIDS. 1997 Jul 15;11(9):1165-71. doi: 10.1097/00002030-199709000-00013.
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Mechanisms of granuloma formation in murine Mycobacterium avium infection: the contribution of CD4+ T cells.小鼠鸟分枝杆菌感染中肉芽肿形成的机制：CD4 + T细胞的作用
Int Immunol. 1996 Aug;8(8):1299-310. doi: 10.1093/intimm/8.8.1299.
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Liposomal amikacin for treatment of M. avium infections in clinically relevant experimental settings.脂质体阿米卡星用于在临床相关实验环境中治疗鸟分枝杆菌感染。
Zentralbl Bakteriol. 1996 Jul;284(2-3):218-31. doi: 10.1016/s0934-8840(96)80097-1.
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Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycobacterium avium infection.脂质体包裹抗生素治疗细胞内鸟分枝杆菌感染的制剂与疗效
Antimicrob Agents Chemother. 1995 Sep;39(9):2104-11. doi: 10.1128/AAC.39.9.2104.
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The Mycobacterium avium complex.鸟分枝杆菌复合体
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Liposomes in the treatment of infections.脂质体在感染治疗中的应用。
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Fluorescence polarization immunoassay. I. Monitoring aminoglycoside antibiotics in serum and plasma.荧光偏振免疫测定法。I. 监测血清和血浆中的氨基糖苷类抗生素。
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Mycobacterium avium complex infection.鸟分枝杆菌复合群感染
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Enhanced effect of liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection in beige mice.脂质体包裹的阿米卡星对米色小鼠鸟分枝杆菌-胞内分枝杆菌复合感染的增强作用。
Antimicrob Agents Chemother. 1988 Sep;32(9):1404-11. doi: 10.1128/AAC.32.9.1404.
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脂质体包裹的阿米卡星延长间隔治疗在实验性鸟分枝杆菌感染中的原理及疗效

Rationale for and efficacy of prolonged-interval treatment using liposome-encapsulated amikacin in experimental Mycobacterium avium infection.

作者信息

Leitzke S, Bucke W, Borner K, Müller R, Hahn H, Ehlers S

机构信息

Department of Infectious Diseases, Benjamin Franklin University Clinic, Free University of Berlin, Germany.

出版信息

Antimicrob Agents Chemother. 1998 Feb;42(2):459-61. doi: 10.1128/AAC.42.2.459.

DOI:10.1128/AAC.42.2.459
PMID:9527808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105436/
Abstract

The potential of liposome-encapsulated antibiotics for prolonging drug application intervals was investigated by using a murine model of chronic lethal Mycobacterium avium infection. Liposomal encapsulation of amikacin, but not of ciprofloxacin, resulted in high and sustained drug levels in infected tissues, exceeding the minimal inhibitory concentration for M. avium for at least 28 days. As a consequence, once-weekly and even once-monthly treatments with liposomal amikacin significantly reduced bacterial replication in infected tissues and extended the survival time of infected mice.

摘要

通过使用慢性致死性鸟分枝杆菌感染的小鼠模型，研究了脂质体包裹抗生素延长药物应用间隔的潜力。阿米卡星脂质体包裹而非环丙沙星脂质体包裹，导致感染组织中药物水平高且持续，超过鸟分枝杆菌的最低抑菌浓度至少28天。因此，每周一次甚至每月一次用脂质体阿米卡星治疗可显著减少感染组织中的细菌复制，并延长感染小鼠的存活时间。