Corrigan F M, Murray L, Wyatt C L, Shore R F
Argyll and Bute NHS Trust, Argyll and Bute Hospital, Lochgilphead, PA31 8LD, United Kingdom.
Exp Neurol. 1998 Apr;150(2):339-42. doi: 10.1006/exnr.1998.6776.
As it had previously been demonstrated that there were reduced brain dopamine concentrations in monkeys who had been given polychlorinated biphenyls (PCBs) chronically, we hypothesized that organochlorine compounds in general, and PCBs in particular, might be important in the pathogenesis of Parkinson's disease (PD). In a study of caudate nucleus obtained post mortem from patients with Parkinson's disease and from controls, there were significantly higher concentrations of the organochlorine insecticide dieldrin and the PCB congener 153 in the PD tissue. DDE, PCB congener 180, and total PCBs (matched with a commercial preparation) also tended to be higher in Parkinson's disease tissue. We think that this is important preliminary evidence that diorthosubstituted PCBs may contribute to the pathogenesis of Parkinson's disease, and a greater presence of organochlorine insecticides in the PD tissue suggests that this may be in part the explanation for the association between PD and rural living.
由于先前已证明，长期摄入多氯联苯（PCBs）的猴子大脑中多巴胺浓度降低，我们推测一般的有机氯化合物，尤其是多氯联苯，可能在帕金森病（PD）的发病机制中起重要作用。在一项对帕金森病患者和对照组死后获取的尾状核的研究中，帕金森病组织中有机氯杀虫剂狄氏剂和多氯联苯同系物153的浓度显著更高。帕金森病组织中的DDE、多氯联苯同系物180以及总多氯联苯（与一种商业制剂匹配）也往往更高。我们认为，这是重要的初步证据，表明邻位二取代多氯联苯可能导致帕金森病的发病机制，并且帕金森病组织中有机氯杀虫剂含量更高表明，这可能部分解释了帕金森病与农村生活之间的关联。
