尿3-甲基组氨酸排泄量：通过计算机断层扫描与全身骨骼肌质量的关联。

Urinary 3-methylhistidine excretion: association with total body skeletal muscle mass by computerized axial tomography.

作者信息

Wang Z, Deurenberg P, Matthews D E, Heymsfield S B

机构信息

Department of Medicine, St Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, USA.

出版信息

JPEN J Parenter Enteral Nutr. 1998 Mar-Apr;22(2):82-6. doi: 10.1177/014860719802200282.

DOI:10.1177/014860719802200282

PMID:9527964

Abstract

BACKGROUND

The urinary excretion of endogenous 3-methylhistidine (3-MH) has been proposed as a predictor of skeletal muscle mass (SM). In this study, we report the relationship between 24-hour urinary 3-MH excretion and SM.

METHODS

Total body SM was measured by multiscan computerized axial tomography (CT) in a sample of 10 healthy adult men who followed a meat-free diet for 7 days. 3-MH was measured during the last 3 days of the meat-free diet protocol on consecutive 24-hour urine collections.

RESULTS

The 3-MH excretion was 216.3 +/- 44.7 mumol/d (mean +/- SD) and was found well associated with SM (in kilograms), SM = 0.0887 x 3-MH + 11.8; r = .88, p < .001. Compared with CT, the previous 3-MH-SM prediction equation suggested by Lukaski et al underestimated SM by an average of 8.9 kg in the 10 healthy men. This difference was caused by the Burkinshaw-Cohn neutron activation model, which underestimated SM and was used as the reference in the Lukaski method.

CONCLUSIONS

Twenty-four-hour urinary 3-MH excretion can be applied for estimating SM in healthy adult men on a meat-free diet.

摘要

背景

内源性3-甲基组氨酸（3-MH）的尿排泄已被提议作为骨骼肌质量（SM）的预测指标。在本研究中，我们报告了24小时尿3-MH排泄与SM之间的关系。

方法

对10名遵循7天无肉饮食的健康成年男性样本，通过多扫描计算机断层扫描（CT）测量全身SM。在无肉饮食方案的最后3天，对连续24小时尿液收集样本测量3-MH。

结果

3-MH排泄量为216.3±44.7μmol/d（均值±标准差），且发现其与SM（以千克计）密切相关，SM = 0.0887×3-MH + 11.8；r = 0.88，p < 0.001。与CT相比，Lukaski等人之前提出的3-MH-SM预测方程在这10名健康男性中平均低估SM 8.9千克。这种差异是由Burkinshaw-Cohn中子活化模型导致的，该模型低估了SM，并在Lukaski方法中用作参考。