Mendez J, Lukaski H C, Buskirk E R
Am J Clin Nutr. 1984 May;39(5):710-5. doi: 10.1093/ajcn/39.5.710.
The relationships between maximal oxygen consumption (VO2max) with fat-free mass (FFM), and with 24-h urinary excretion of 3-methylhistidine (3MH) and creatinine (Cr), were studied in 12 active men age 31.4 +/- 9 yr (mean +/- SD). FFM, VO2max and VO2maxWt-1 were 50.9 +/- 9.1 kg, 3.8 +/- 0.9 L X min-1, and 54.8 +/- 9.4 ml X kg-1 X min-1, respectively. Urinary 3MH and Cr after 3 days on a meat-free diet were 213.9 +/- 30.8 mumol X day-1 and 1.60 +/- 0.3 g X day-1, respectively. 3MH X Cr-1 was 135.3 +/- 16.8 mumol X g-1 or 15.3 +/- 1.9 molar ratio X 10(3). The strongest (p less than 0.01) associations found were 3MH versus FFM, FFM versus VO2max, and 3MH versus VO2max. Other significant (p less than 0.05) relationships were Cr versus FFM, Cr versus 3MH, and Cr versus VO2max. Nonsignificant correlations were found for 3MH X Cr-1 versus VO2max X kg-1 X min-1 versus FFM, 3MH X Cr-1 versus VO2max, and FFM versus VO2max X kg-1 X min-1. The best predictor of FFM was 3MH. It was concluded that endogenous urinary 3MH excretion is a valid method to study human body composition and that 3MH is more closely related to FFM (r = 0.93) than VO2max (r = 0.78).
对12名年龄为31.4±9岁（平均±标准差）的活跃男性，研究了最大摄氧量（VO2max）与去脂体重（FFM）、以及与3-甲基组氨酸（3MH）和肌酐（Cr）的24小时尿排泄量之间的关系。FFM、VO2max和VO2maxWt-1分别为50.9±9.1千克、3.8±0.9升·分钟-1和54.8±9.4毫升·千克-1·分钟-1。无肉饮食3天后，尿中3MH和Cr分别为213.9±30.8微摩尔·天-1和1.60±0.3克·天-1。3MH×Cr-1为135.3±16.8微摩尔·克-1或15.3±1.9摩尔比×10(3)。发现的最强关联（p<0.01）为3MH与FFM、FFM与VO2max、以及3MH与VO2max。其他显著（p<0.05）关系为Cr与FFM、Cr与3MH、以及Cr与VO2max。对于3MH×Cr-1与VO2max×千克-1·分钟-1与FFM、3MH×Cr-1与VO2max、以及FFM与VO2max×千克-1·分钟-1，未发现显著相关性。FFM的最佳预测指标是3MH。得出结论，内源性尿3MH排泄是研究人体成分的有效方法，且3MH与FFM（r=0.93）的关系比与VO2max（r=0.78）更密切。
