de Andrés C, Lledó A
Servicio de Neurología, Hospital General Gregorio Marañón, Madrid, España.
Rev Neurol. 1997 Dec;25(148):2032-5.
Multiple sclerosis (ME) is an inflammatory disease of the myelin of the central nervous system, the origin of which is still unknown. Genetic, infectious, immunological and environmental factors have all been blamed, but none of these factors on their own can explain the whole spectrum of this disease. Of the environmental factors, fat in the diet has given rise to most discussion. At the present time, it is known that polyunsaturated essential fatty acids form a part of biological membranes. A relationship has been found between the dietary fat consumed and the plasma levels and cell membrane content.
The possible immuno-modulation function of these fatty acids justify rigorous evaluation of this hypothesis.
多发性硬化症(MS)是一种中枢神经系统髓鞘的炎症性疾病,其病因仍不明。遗传、感染、免疫和环境因素都曾被指责,但这些因素单独都无法解释该疾病的全貌。在环境因素中,饮食中的脂肪引发了最多讨论。目前已知多不饱和必需脂肪酸是生物膜的一部分。已发现摄入的膳食脂肪与血浆水平及细胞膜含量之间存在关联。
这些脂肪酸可能的免疫调节功能证明了对这一假说进行严格评估的合理性。