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[将感染传播降至最低的政策方案。长期咳嗽可能是肺结核的症状]。

[Policy program to minimize spread of infection. Prolonged cough may be a sign of tuberculosis].

作者信息

Fredlund H, Larsson L O, Blom-Bülow B, Julander I, Normann B, Romanus V, Wahlström H

机构信息

Smittskyddsenheten, Regionsjukhuset, Orebro.

出版信息

Lakartidningen. 1998 Mar 4;95(10):1010-2, 1015-6.

PMID:9528251
Abstract

In a worldwide epidemiological perspective, Sweden is well favoured with an annual tuberculosis incidence of approximately six cases per 100,000 of the population. Neither the impact of the HIV pandemic nor the occurrence of multiresistant strains of Mycobacterium tuberculosis has yet become a major problem in the care of tuberculosis patients in Sweden. Only a few per cent of HIV patients have developed tuberculosis, and during the period, 1991-94, only one per cent of M. tuberculosis isolates in Sweden were resistant to such antimycobacterials as isoniazid and rifampicin. However, the epidemiological situation in the neighbouring Baltic states is a matter for concern. Bovine tuberculosis has been eradicated in Sweden, the last case having been diagnosed in 1978. Although the reported efficacy of BCG (bacillus Calmette-Guérin) tuberculosis vaccine varies according to the population studied, protective rates of 70-85 per cent have been reported for Sweden and other west European countries. Re-vaccination of tuberculin-negative individuals has not been shown to yield added protection. The aim of a national programme for protection against tuberculosis is to preserve our favourable epidemiological situation by early detection of new cases, effective contact tracing, and BCG vaccination of children in population groups at risk. The primary means of achieving this is the education of health care personnel to retain tuberculosis as a differential diagnosis. Moreover, national guidelines for contact tracing must be duly observed, and immigrants from high prevalence areas need to be screened for tuberculosis. Registration of all cases of tuberculosis should be maintained at regional and national levels, and follow-up must be meticulous until a successful outcome of treatment is accomplished. Recommendations for dealing with tuberculosis should be made available and duly implemented at all hospitals caring for tuberculosis patients, in order to avoid nosocomial transmission. Although BCG vaccination at birth was formerly general in Sweden, since 1975 only children considered to be at risk have been vaccinated. Thus, non-vaccinated young adults are now entering the health care sector as students or employees, and should be offered BCG vaccination. Moreover, the epidemiological situation both in Sweden and in neighbouring countries needs to be monitored carefully in order that recommendations concerning BCG vaccination and other preventive measures can be modified if necessary.

摘要

从全球流行病学角度来看,瑞典的结核病发病率较低,每年每10万人口中约有6例。在瑞典,艾滋病大流行的影响以及结核分枝杆菌多重耐药菌株的出现都尚未成为结核病患者护理中的主要问题。只有少数艾滋病患者感染了结核病,在1991年至1994年期间,瑞典分离出的结核分枝杆菌中只有1%对异烟肼和利福平之类的抗分枝杆菌药物耐药。然而,邻国波罗的海国家的流行病学状况令人担忧。瑞典已根除牛结核病,最后一例于1978年确诊。尽管据报道卡介苗(Bacillus Calmette-Guérin)结核病疫苗的疗效因所研究的人群而异,但瑞典和其他西欧国家报告的保护率为70%至85%。尚未证明对结核菌素阴性个体进行再次接种能提供额外保护。国家结核病预防计划的目标是通过早期发现新病例、有效追踪接触者以及对高危人群中的儿童进行卡介苗接种,来保持我们有利的流行病学状况。实现这一目标的主要手段是教育医护人员将结核病作为鉴别诊断。此外,必须严格遵守国家接触者追踪指南,对来自高流行地区的移民进行结核病筛查。所有结核病病例应在地区和国家层面进行登记,并且必须进行细致的随访,直到治疗取得成功结果。所有治疗结核病患者的医院都应提供并适当实施结核病治疗建议,以避免医院内传播。虽然以前在瑞典出生时普遍接种卡介苗,但自1975年以来,只有被认为有风险的儿童才接种。因此,未接种疫苗的年轻人现在作为学生或员工进入医疗保健行业,应提供卡介苗接种。此外,需要仔细监测瑞典及其邻国的流行病学状况,以便在必要时修改有关卡介苗接种和其他预防措施的建议。

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