Nilsson P
Klinisk forskningsenhet, Universitetssjukhuset, Malmö.
Nord Med. 1998 Mar;113(3):82-4.
Smoking, lipid disorders, hypertension and diabetes are well known risk factors for cardiovascular disease. Many individuals are characterised by a genetically determined predisposition and moreover, psychosocial factors and an inappropriate life style may exert adverse effects on biological variables. Evidence exists which suggests that in such cases various ageing processes may be accelerated. Studies of apoptosis regulation can yield improved understanding of such phenomena as atherosclerotic plaque rupture and such structural cardiovascular changes as left ventricular hypertrophy. A possible clinical result of such events may be manifest myocardial infarction, followed by heart failure and a predisposition to arrhythmia. The recent identification of apopain, a proteolytic enzyme associated with apoptosis, may eventually enable drugs to be developed for the regulation of apoptosis.
吸烟、脂代谢紊乱、高血压和糖尿病是众所周知的心血管疾病风险因素。许多人具有遗传决定的易感性，此外，社会心理因素和不恰当的生活方式可能会对生物变量产生不利影响。有证据表明，在这些情况下，各种衰老过程可能会加速。对细胞凋亡调节的研究可以更好地理解动脉粥样硬化斑块破裂等现象以及左心室肥厚等心血管结构变化。这些事件可能导致的临床后果可能是明显的心肌梗死，继而出现心力衰竭和心律失常倾向。最近发现的凋亡蛋白酶，一种与细胞凋亡相关的蛋白水解酶，最终可能使开发调节细胞凋亡的药物成为可能。
