Aass N, Fosså S D, Dahl A A, Moe T J
Onkologisk avdeling, Det Norske Radiumhospital, Oslo.
Tidsskr Nor Laegeforen. 1998 Feb 20;118(5):698-703.
The prevalence of anxiety and depression was evaluated in 716 unselected hospitalised patients and out-patients seen at the Norwegian Radium Hospital using the Hospital Anxiety and Depression Scale (HADS), the EORTC QLQ-C33 and an ad hoc designed questionnaire, the latter assessing socio-demographic data and disease-related parameters. The prevalence of anxiety and depression was 13% and 9%, respectively, as assessed with the HADS. In the logistic regression analysis, none of the disease-related factors remained independent parameters predictive for psychiatric distress, whereas a history of previous psychiatric problems and impaired social life were correlated both with anxiety and depression. Female gender, impaired physical activity and impaired social role function were additional predictive parameters for anxiety, whereas fatigue predicted depression. Careful attention should be paid to cancer patients displaying these significant problems in order to diagnose and treat depression and anxiety disorders of clinical importance.
采用医院焦虑抑郁量表（HADS）、欧洲癌症研究与治疗组织核心生活质量问卷（QLQ-C33）以及一份专门设计的问卷，对挪威镭医院的716名未经挑选的住院患者和门诊患者的焦虑和抑郁患病率进行了评估。后者用于评估社会人口统计学数据和疾病相关参数。根据HADS评估，焦虑和抑郁的患病率分别为13%和9%。在逻辑回归分析中，没有一个疾病相关因素仍然是预测精神痛苦的独立参数，而既往有精神问题史和社会生活受损与焦虑和抑郁均相关。女性、身体活动受损和社会角色功能受损是焦虑的额外预测参数，而疲劳则预测抑郁。对于表现出这些严重问题的癌症患者，应予以密切关注，以便诊断和治疗具有临床意义的抑郁和焦虑障碍。
