Gran J T
Revmatologisk avdeling, Regionsykehuset i Tromsø.
Tidsskr Nor Laegeforen. 1998 Feb 20;118(5):710-4.
The systemic connective tissue diseases represent a broad spectrum of multiorgan disorders. This report reviews our current knowledge of mortality and the risk of cancer in these diseases. The relationship between clinical manifestations and reduced survival in systemic sclerosis, systemic lupus erythematosus and polyarteritis nodosa is addressed in detail. Moreover, we outline the increased risks of cancer in dermatomyositis and lymphoma in primary Sjögren's syndrome, as well as cancer of the bladder in patients with Wegener's granulomatosis who have been treated with cyclophosphamide. Finally, the conflicting results regarding mortality in temporal arteritis are discussed.
系统性结缔组织病是一类广泛的多器官疾病。本报告回顾了我们目前对这些疾病的死亡率和患癌风险的认识。详细阐述了系统性硬化症、系统性红斑狼疮和结节性多动脉炎的临床表现与生存率降低之间的关系。此外，我们概述了皮肌炎患癌风险增加、原发性干燥综合征患者患淋巴瘤的风险，以及接受环磷酰胺治疗的韦格纳肉芽肿病患者患膀胱癌的风险。最后，讨论了颞动脉炎死亡率方面相互矛盾的结果。
