曲伐沙星与氧氟沙星单剂量治疗淋病的随机试验。曲伐沙星淋病研究组。
Randomized trial of trovafloxacin and ofloxacin for single-dose therapy of gonorrhea. Trovafloxacin Gonorrhea Study Group.
作者信息
Jones R B, Schwebke J, Thorpe E M, Dalu Z A, Leone P, Johnson R B
机构信息
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5124, USA.
出版信息
Am J Med. 1998 Jan;104(1):28-32. doi: 10.1016/s0002-9343(97)00277-5.
PURPOSE
To compare trovafloxacin, a new quinolone antibiotic with enhanced activity against Neisseria gonorrhoeae, with ofloxacin as single-dose oral therapy for uncomplicated gonococcal urethritis or cervicitis.
PATIENTS AND METHODS
In this multicenter, double-blind trial, 625 patients (270 men, 355 women) with uncomplicated gonococcal urethritis or cervicitis received one 100-mg tablet of trovafloxacin or two 200-mg capsules of ofloxacin as a single dose under direct supervision.
RESULTS
Single-dose oral therapy with trovafloxacin was equivalent both bacteriologically and clinically to ofloxacin. Among evaluable patients, N gonorrhoeae was eradicated in 99% of trovafloxacin recipients and in 98% of ofloxacin recipients. Each treatment was well tolerated; vaginitis was the most frequently observed side effect (4% trovafloxacin, 7% ofloxacin).
CONCLUSION
Based on the results presented here, trovafloxacin is a promising agent for single-dose therapy of uncomplicated gonorrhea.
目的
比较新型喹诺酮类抗生素曲伐沙星（对淋病奈瑟菌活性增强）与氧氟沙星作为单剂量口服疗法治疗单纯性淋菌性尿道炎或宫颈炎的效果。
患者与方法
在这项多中心双盲试验中，625例单纯性淋菌性尿道炎或宫颈炎患者（男性270例，女性355例）在直接监督下接受单剂量的1片100毫克曲伐沙星或2粒200毫克氧氟沙星胶囊治疗。
结果
曲伐沙星单剂量口服疗法在细菌学和临床方面与氧氟沙星相当。在可评估的患者中，99%接受曲伐沙星治疗的患者和98%接受氧氟沙星治疗的患者的淋病奈瑟菌被根除。每种治疗的耐受性都良好；阴道炎是最常观察到的副作用（曲伐沙星为4%，氧氟沙星为7%）。
结论
基于此处给出的结果，曲伐沙星是单纯性淋病单剂量治疗的一种有前景的药物。
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