变形链球菌抗原I/II的粘附结构域与结构区域在大鼠鼻内免疫后抗龋齿保护性免疫中的比较
Comparison of an adherence domain and a structural region of Streptococcus mutans antigen I/II in protective immunity against dental caries in rats after intranasal immunization.
作者信息
Hajishengallis G, Russell M W, Michalek S M
机构信息
Department of Microbiology, University of Alabama at Birmingham, 35294, USA.
出版信息
Infect Immun. 1998 Apr;66(4):1740-3. doi: 10.1128/IAI.66.4.1740-1743.1998.
Abstract
Previous studies have identified an N-terminal saliva-binding region (SBR) on Streptococcus mutans surface antigen I/II (AgI/II) and suggested its importance in the initial adherence of S. mutans to saliva-coated tooth surfaces and subsequent development of dental caries. In this study, we compared the SBR with a C-terminal structural region of AgI/II (AgII) in their abilities to induce protective immunity against caries in rats. When SBR, AgII, or the whole AgI/II molecule was administered intranasally as a conjugate with the B subunit of cholera toxin (CT), in the presence of CT adjuvant, substantial levels of salivary immunoglobulin A anti-AgI/II antibodies were induced. Evaluation of caries activity showed that the SBR, though not as protective as the parent molecule, was superior to AgII and thus can be further considered as a component in a multivalent caries vaccine.
摘要
先前的研究已在变形链球菌表面抗原I/II（AgI/II）上鉴定出一个N端唾液结合区域（SBR），并表明其在变形链球菌初始黏附于唾液包被的牙齿表面以及随后龋齿发展过程中的重要性。在本研究中，我们比较了SBR与AgI/II的C端结构区域（AgII）诱导大鼠抗龋齿保护性免疫的能力。当SBR、AgII或整个AgI/II分子与霍乱毒素（CT）的B亚基作为偶联物经鼻内给药时，在CT佐剂存在的情况下，可诱导出高水平的唾液免疫球蛋白A抗AgI/II抗体。龋齿活性评估表明，SBR虽然不如亲本分子具有保护性，但优于AgII，因此可进一步被视为多价龋齿疫苗的一个成分。
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