用与霍乱毒素A2/B亚基基因连接的细菌蛋白抗原进行口服免疫后血清和唾液抗体反应的持久性。
Persistence of serum and salivary antibody responses after oral immunization with a bacterial protein antigen genetically linked to the A2/B subunits of cholera toxin.
作者信息
Hajishengallis G, Michalek S M, Russell M W
机构信息
Department of Microbiology, University of Alabama at Birmingham 35294, USA.
出版信息
Infect Immun. 1996 Feb;64(2):665-7. doi: 10.1128/iai.64.2.665-667.1996.
Abstract
Primary oral immunization of mice with a bacterial protein antigen genetically coupled to the A2 and B subunits of cholera toxin induced specific secretory immunoglobulin A and serum immunoglobulin G antibodies that persisted at substantial levels for at least 11 months. A subsequent single booster immunization did not further enhance the antibody responses. Long-term antibody persistence may be especially important in infections caused by common pathogens for which continuous immunity would be advantageous.
摘要
用与霍乱毒素A2和B亚基基因偶联的细菌蛋白抗原对小鼠进行初次口服免疫，可诱导产生特异性分泌型免疫球蛋白A和血清免疫球蛋白G抗体，这些抗体至少在11个月内持续保持较高水平。随后的单次加强免疫并未进一步增强抗体反应。对于常见病原体引起的感染，长期抗体持续存在可能尤为重要，因为持续免疫将具有优势。
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