衰老与对b型流感嗜血杆菌荚膜多糖的免疫反应：老年人中优势独特型及抗体功能的保留
Aging and the immune response to the Haemophilus influenzae type b capsular polysaccharide: retention of the dominant idiotype and antibody function in the elderly.
作者信息
Lucas A H, Reason D C
机构信息
Children's Hospital Oakland Research Institute, California 94609, USA.
出版信息
Infect Immun. 1998 Apr;66(4):1752-4. doi: 10.1128/IAI.66.4.1752-1754.1998.
Abstract
Anti-Haemophilus influenzae b polysaccharide (Hib PS) antibodies elicited in elderly subjects following conjugate vaccination expressed a light-chain variable-region (VL)-associated idiotype and had functional activities similar to those previously observed in children and younger adults. These findings indicate that advanced age is not accompanied by shifts in the major VL component of the Hib PS-specific repertoire or by diminution of the protective function of antibodies.
摘要
在老年受试者中，结合疫苗接种后产生的抗b型流感嗜血杆菌多糖（Hib PS）抗体表达了一种与轻链可变区（VL）相关的独特型，并且具有与先前在儿童和年轻成年人中观察到的类似的功能活性。这些发现表明，高龄并不会伴随着Hib PS特异性抗体库中主要VL成分的改变，也不会导致抗体保护功能的减弱。
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