人类肠道上皮细胞对微小隐孢子虫感染的反应是前列腺素H合酶2表达增加以及前列腺素E2和F2α生成增多。
Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production.
作者信息
Laurent F, Kagnoff M F, Savidge T C, Naciri M, Eckmann L
机构信息
Department of Medicine, University of California, San Diego, La Jolla 92093, USA.
出版信息
Infect Immun. 1998 Apr;66(4):1787-90. doi: 10.1128/IAI.66.4.1787-1790.1998.
Abstract
Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. Here, we show that C. parvum infection directly activates prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production in human intestinal epithelial cells.
摘要
微小隐孢子虫是人类和多种动物腹泻的重要病因。在隐孢子虫病动物模型中，前列腺素在调节肠道液体分泌方面发挥着核心作用，但其细胞来源和诱导机制尚不清楚。在此，我们表明微小隐孢子虫感染可直接激活人肠上皮细胞中前列腺素H合酶2的表达以及前列腺素E2和F2α的产生。
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本文引用的文献
1
Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines.微小隐孢子虫对人肠上皮细胞的感染会诱导C-X-C趋化因子的极化分泌。
Infect Immun. 1997 Dec;65(12):5067-73. doi: 10.1128/iai.65.12.5067-5073.1997.
2
Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production.肠道上皮细胞在宿主对侵袭性细菌感染的分泌反应中的作用。细菌侵入诱导上皮细胞前列腺素h合酶-2表达以及前列腺素E2和F2α的产生。
J Clin Invest. 1997 Jul 15;100(2):296-309. doi: 10.1172/JCI119535.
3
Role of the enteric nervous system in piglet cryptosporidiosis.肠道神经系统在仔猪隐孢子虫病中的作用。
J Pharmacol Exp Ther. 1996 Dec;279(3):1109-15.
4
Prostaglandin endoperoxide synthase: why two isoforms?前列腺素内过氧化物合酶：为何有两种同工型？
Am J Physiol. 1996 Mar;270(3 Pt 1):G393-400. doi: 10.1152/ajpgi.1996.270.3.G393.
5
Prostanoids inhibit intestinal NaCl absorption in experimental porcine cryptosporidiosis.前列腺素在实验性猪隐孢子虫病中抑制肠道氯化钠吸收。
Gastroenterology. 1993 Feb;104(2):440-7. doi: 10.1016/0016-5085(93)90412-6.
6
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Gastroenterology. 1994 Jan;106(1):252-4. doi: 10.1016/s0016-5085(94)95891-2.
7
An intestinal xenograft model for Cryptosporidium parvum infection.一种用于微小隐孢子虫感染的肠道异种移植模型。
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8
Duodenal morphology and intensity of infection in AIDS-related intestinal cryptosporidiosis.艾滋病相关肠道隐孢子虫病的十二指肠形态及感染强度
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9
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro.新型抗炎药NS - 398在体外可选择性抑制前列腺素G/H合成酶/环氧化酶（COX - 2）的活性。
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