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1
Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production.人类肠道上皮细胞对微小隐孢子虫感染的反应是前列腺素H合酶2表达增加以及前列腺素E2和F2α生成增多。
Infect Immun. 1998 Apr;66(4):1787-90. doi: 10.1128/IAI.66.4.1787-1790.1998.
2
Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production.肠道上皮细胞在宿主对侵袭性细菌感染的分泌反应中的作用。细菌侵入诱导上皮细胞前列腺素h合酶-2表达以及前列腺素E2和F2α的产生。
J Clin Invest. 1997 Jul 15;100(2):296-309. doi: 10.1172/JCI119535.
3
Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells.新生鼠肠道代谢产物影响肠道上皮细胞中微小隐孢子虫的感染。
mBio. 2020 Dec 15;11(6):e02582-20. doi: 10.1128/mBio.02582-20.
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Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C. parvum-infected porcine ileum.一氧化氮合酶刺激微小隐孢子虫感染的猪回肠中的前列腺素合成和屏障功能。
Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G571-81. doi: 10.1152/ajpgi.00413.2003. Epub 2004 May 20.
5
Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines.微小隐孢子虫对人肠上皮细胞的感染会诱导C-X-C趋化因子的极化分泌。
Infect Immun. 1997 Dec;65(12):5067-73. doi: 10.1128/iai.65.12.5067-5073.1997.
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Induction of a Long Noncoding RNA Transcript, NR_045064, Promotes Defense Gene Transcription and Facilitates Intestinal Epithelial Cell Responses against Infection.诱导长非编码 RNA 转录本 NR_045064 促进防御基因转录并有助于肠道上皮细胞对 感染的反应。
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Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection.干扰素-λ3 促进上皮防御和屏障功能抵抗微小隐孢子虫感染。
Cell Mol Gastroenterol Hepatol. 2019;8(1):1-20. doi: 10.1016/j.jcmgh.2019.02.007. Epub 2019 Mar 5.
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Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells.微小隐孢子虫附着并内化至胆管和肠上皮细胞的机制。
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NF-kappaB-mediated expression of iNOS promotes epithelial defense against infection by Cryptosporidium parvum in neonatal piglets.核因子-κB介导的诱导型一氧化氮合酶表达促进新生仔猪抵御微小隐孢子虫感染的上皮防御。
Am J Physiol Gastrointest Liver Physiol. 2006 Jan;290(1):G164-74. doi: 10.1152/ajpgi.00460.2004. Epub 2005 Aug 25.
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Bovine TLR2 and TLR4 mediate Cryptosporidium parvum recognition in bovine intestinal epithelial cells.牛TLR2和TLR4介导牛肠道上皮细胞中微小隐孢子虫的识别。
Microb Pathog. 2015 Aug;85:29-34. doi: 10.1016/j.micpath.2015.05.009. Epub 2015 Jun 3.

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Cryptosporidiosis in a Zoonotic Gastrointestinal Disorder Perspective: Present Status, Risk Factors, Pathophysiology, and Treatment, Particularly in Immunocompromised Patients.人畜共患胃肠道疾病视角下的隐孢子虫病：现状、危险因素、病理生理学及治疗，尤其针对免疫功能低下患者
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2
Gene expression profile of HCT-8 cells following single or co-infections with Cryptosporidium parvum and bovine coronavirus.单纯感染和共同感染微小隐孢子虫和牛冠状病毒后 HCT-8 细胞的基因表达谱。
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The Long Non-Coding RNA Nostrill Regulates Transcription of Irf7 Through Interaction With NF-κB p65 to Enhance Intestinal Epithelial Defense Against .长非编码 RNA Nostrill 通过与 NF-κB p65 相互作用调控 Irf7 的转录从而增强肠道上皮防御功能
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6
Dual Transcriptomics To Determine Gamma Interferon-Independent Host Response to Intestinal Cryptosporidium parvum Infection.双重转录组学确定肠道隐孢子虫感染中γ干扰素非依赖性宿主反应。
Infect Immun. 2022 Feb 17;90(2):e0063821. doi: 10.1128/iai.00638-21. Epub 2021 Dec 20.
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LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense.LncRNA XR_001779380 启动上皮细胞中 IFN-γ 介导的基因转录并促进年龄相关的肠道抗菌防御。
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Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense.隐孢子虫感染抑制肠道上皮细胞丝裂原活化蛋白激酶信号传导，损害宿主抗寄生虫防御。
Microorganisms. 2021 Jan 12;9(1):151. doi: 10.3390/microorganisms9010151.
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You Talking to Me? Says the Enteric Nervous System (ENS) to the Microbe. How Intestinal Microbes Interact with the ENS.“你在和我说话吗？”肠神经系统（ENS）对微生物说道。肠道微生物如何与肠神经系统相互作用。
J Clin Med. 2020 Nov 18;9(11):3705. doi: 10.3390/jcm9113705.
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Induction of Inflammatory Responses in Splenocytes by Exosomes Released from Intestinal Epithelial Cells following Infection.肠上皮细胞来源的外泌体感染诱导脾细胞炎症反应。
Infect Immun. 2019 Mar 25;87(4). doi: 10.1128/IAI.00705-18. Print 2019 Apr.

本文引用的文献

1
Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines.微小隐孢子虫对人肠上皮细胞的感染会诱导C-X-C趋化因子的极化分泌。
Infect Immun. 1997 Dec;65(12):5067-73. doi: 10.1128/iai.65.12.5067-5073.1997.
2
Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production.肠道上皮细胞在宿主对侵袭性细菌感染的分泌反应中的作用。细菌侵入诱导上皮细胞前列腺素h合酶-2表达以及前列腺素E2和F2α的产生。
J Clin Invest. 1997 Jul 15;100(2):296-309. doi: 10.1172/JCI119535.
3
Role of the enteric nervous system in piglet cryptosporidiosis.肠道神经系统在仔猪隐孢子虫病中的作用。
J Pharmacol Exp Ther. 1996 Dec;279(3):1109-15.
4
Prostaglandin endoperoxide synthase: why two isoforms?前列腺素内过氧化物合酶：为何有两种同工型？
Am J Physiol. 1996 Mar;270(3 Pt 1):G393-400. doi: 10.1152/ajpgi.1996.270.3.G393.
5
Prostanoids inhibit intestinal NaCl absorption in experimental porcine cryptosporidiosis.前列腺素在实验性猪隐孢子虫病中抑制肠道氯化钠吸收。
Gastroenterology. 1993 Feb;104(2):440-7. doi: 10.1016/0016-5085(93)90412-6.
6
Cryptosporidiosis: the complexity of intestinal pathophysiology.隐孢子虫病：肠道病理生理学的复杂性
Gastroenterology. 1994 Jan;106(1):252-4. doi: 10.1016/s0016-5085(94)95891-2.
7
An intestinal xenograft model for Cryptosporidium parvum infection.一种用于微小隐孢子虫感染的肠道异种移植模型。
Infect Immun. 1994 Jan;62(1):329-31. doi: 10.1128/iai.62.1.329-331.1994.
8
Duodenal morphology and intensity of infection in AIDS-related intestinal cryptosporidiosis.艾滋病相关肠道隐孢子虫病的十二指肠形态及感染强度
Gastroenterology. 1993 Dec;105(6):1769-75. doi: 10.1016/0016-5085(93)91075-s.
9
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro.新型抗炎药NS - 398在体外可选择性抑制前列腺素G/H合成酶/环氧化酶（COX - 2）的活性。
Prostaglandins. 1994 Jan;47(1):55-9. doi: 10.1016/0090-6980(94)90074-4.
10
A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.作为对细菌入侵的反应，人类结肠上皮细胞会表达一系列独特的促炎细胞因子。
J Clin Invest. 1995 Jan;95(1):55-65. doi: 10.1172/JCI117676.

人类肠道上皮细胞对微小隐孢子虫感染的反应是前列腺素H合酶2表达增加以及前列腺素E2和F2α生成增多。

Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production.

作者信息

Laurent F, Kagnoff M F, Savidge T C, Naciri M, Eckmann L

机构信息

Department of Medicine, University of California, San Diego, La Jolla 92093, USA.

出版信息

Infect Immun. 1998 Apr;66(4):1787-90. doi: 10.1128/IAI.66.4.1787-1790.1998.

DOI:10.1128/IAI.66.4.1787-1790.1998
PMID:9529115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC108122/
Abstract

Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. Here, we show that C. parvum infection directly activates prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production in human intestinal epithelial cells.

摘要

微小隐孢子虫是人类和多种动物腹泻的重要病因。在隐孢子虫病动物模型中，前列腺素在调节肠道液体分泌方面发挥着核心作用，但其细胞来源和诱导机制尚不清楚。在此，我们表明微小隐孢子虫感染可直接激活人肠上皮细胞中前列腺素H合酶2的表达以及前列腺素E2和F2α的产生。