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硕大利什曼原虫感染巨噬细胞后蛋白激酶C亚型的分布

Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.

作者信息

Pingel S, Wang Z E, Locksley R M

机构信息

Department of Medicine, University of California San Francisco, 94143-0654, USA.

出版信息

Infect Immun. 1998 Apr;66(4):1795-9. doi: 10.1128/IAI.66.4.1795-1799.1998.

DOI:10.1128/IAI.66.4.1795-1799.1998
PMID:9529117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC108124/
Abstract

We characterized the effects of Leishmania infection on activation-induced translocation of protein kinase C (PKC) isoforms in murine bone marrow-derived macrophages. Although PKC-dependent gene expression was attenuated by infection, the distribution and translocation of PKC isoforms were unaffected. However, subsequent dissociation from membranes was substantially delayed for some isoforms, particularly PKCbeta.

摘要

我们研究了利什曼原虫感染对小鼠骨髓来源巨噬细胞中蛋白激酶C（PKC）亚型激活诱导易位的影响。尽管感染会减弱PKC依赖性基因表达，但PKC亚型的分布和易位并未受到影响。然而，随后某些亚型从细胞膜上解离的过程被显著延迟，尤其是PKCβ。

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本文引用的文献

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Br J Pharmacol. 1997 Mar;120(5):940-6. doi: 10.1038/sj.bjp.0700976.
2
Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties.疟原虫、锥虫和利什曼原虫的糖基磷脂酰肌醇在巨噬细胞中的信号转导：肌醇聚糖和二酰基甘油部分对蛋白酪氨酸激酶和蛋白激酶C的激活作用。
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4022-7. doi: 10.1073/pnas.94.8.4022.
3
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Curr Opin Cell Biol. 1997 Apr;9(2):161-7. doi: 10.1016/s0955-0674(97)80058-0.
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Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis.神经酰胺诱导蛋白激酶C-δ和-ε转位至胞质溶胶。对细胞凋亡的影响。
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6
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