硕大利什曼原虫感染巨噬细胞后蛋白激酶C亚型的分布
Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
作者信息
Pingel S, Wang Z E, Locksley R M
机构信息
Department of Medicine, University of California San Francisco, 94143-0654, USA.
出版信息
Infect Immun. 1998 Apr;66(4):1795-9. doi: 10.1128/IAI.66.4.1795-1799.1998.
Abstract
We characterized the effects of Leishmania infection on activation-induced translocation of protein kinase C (PKC) isoforms in murine bone marrow-derived macrophages. Although PKC-dependent gene expression was attenuated by infection, the distribution and translocation of PKC isoforms were unaffected. However, subsequent dissociation from membranes was substantially delayed for some isoforms, particularly PKCbeta.
摘要
我们研究了利什曼原虫感染对小鼠骨髓来源巨噬细胞中蛋白激酶C（PKC）亚型激活诱导易位的影响。尽管感染会减弱PKC依赖性基因表达，但PKC亚型的分布和易位并未受到影响。然而，随后某些亚型从细胞膜上解离的过程被显著延迟，尤其是PKCβ。
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