一种钙诱导胞吐作用的简单模型。

A simple model for calcium induced exocytosis.

作者信息

Hall J E, Simon S A

出版信息

Biochim Biophys Acta. 1976 Jul 1;436(3):613-6. doi: 10.1016/0005-2736(76)90444-2.

Abstract

We have developed a simple model showing how the presence or obsence of Ca2+ can determine whether an uncurved or curved membrane surface is favored energetically. The model shows why fusion of vesicles with the presynaptic membrane is favored in the presence of calcium and why the budding off of vesicles is favored in the absence of calcium inside of the presynaptic membrane. The model accurately predicts the radius of a synaptic vesicle using known properties of lipids and suggests consequences of temperature change, varied stimulation rate and addition of calcium by artificial means on rates of transmitter release.

摘要

我们已经开发出一个简单的模型，该模型展示了钙离子的存在与否如何在能量上决定膜表面是平的还是弯曲的更有利。该模型解释了为什么在有钙的情况下，囊泡与突触前膜的融合更有利，以及为什么在突触前膜内没有钙的情况下，囊泡的出芽更有利。该模型利用已知的脂质特性准确地预测了突触囊泡的半径，并提出了温度变化、不同的刺激速率以及通过人工手段添加钙对神经递质释放速率的影响。