Lasky M R, Metzler M H, Phillips J O
Department of Anesthesiology, University of Missouri, Columbia 65212, USA.
J Trauma. 1998 Mar;44(3):527-33. doi: 10.1097/00005373-199803000-00020.
To prospectively evaluate the incidence of clinically significant bleeding, side effects, and cost of therapy in mechanically ventilated trauma patients at high risk for stress ulcers who received simplified omeprazole suspension (SOS).
Prospective, evaluative study in a Level I trauma center. Mechanically ventilated trauma patients admitted with at least one additional risk factor for stress ulcer development received SOS for stress ulcer prophylaxis.
Sixty trauma patients were enrolled. The mean Injury Severity Score was 27.3. After starting SOS, there were no cases of clinically significant upper gastrointestinal bleeding related to stress ulceration. Baseline pH was 3.3, and mean gastric pH after SOS was increased to 6.7 (p < 0.005). There were no adverse effects thought to be related to omeprazole suspension. Incidence of nosocomial pneumonia after beginning SOS was 28.3%. The cost of acquisition plus administration of SOS was $13.13 per day, whereas the cost of drug acquisition alone was $3.83 per day.
In a prospective, evaluative study of 60 trauma patients who required mechanical ventilation and had at least one additional risk factor for stress ulcer development, omeprazole suspension prevented clinically significant gastrointestinal bleeding, maintained excellent control of gastric pH, produced no toxicity, and was the least costly medication alternative.
前瞻性评估接受简化奥美拉唑混悬液（SOS）治疗的机械通气创伤患者发生具有临床意义的出血、副作用及治疗费用情况。
在一级创伤中心进行的前瞻性评估研究。因至少存在一项应激性溃疡发生额外危险因素而入院的机械通气创伤患者接受SOS预防应激性溃疡。
纳入60例创伤患者。平均损伤严重度评分27.3。开始使用SOS后，无与应激性溃疡相关的具有临床意义的上消化道出血病例。基线pH值为3.3，使用SOS后平均胃内pH值升至6.7（p<0.005）。未发现与奥美拉唑混悬液相关的不良反应。开始使用SOS后医院获得性肺炎的发生率为28.3%。SOS的购置加给药费用为每天13.13美元，而仅药物购置费用为每天3.83美元。
在一项针对60例需要机械通气且至少存在一项应激性溃疡发生额外危险因素的创伤患者的前瞻性评估研究中，奥美拉唑混悬液可预防具有临床意义的胃肠道出血，维持对胃内pH值的良好控制，无毒性，且是成本最低的药物选择。
